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Bio-inspired self-organizing cellular systems

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Grand canonical Brownian dynamics simulations of adsorption and self-assembly of SAS-6 rings on a surface

Pierre Gönczy, Niccolo Banterle

The Spindle Assembly Abnormal Protein 6 (SAS-6) forms dimers, which then self-assemble into rings that are critical for the nine-fold symmetry of the centriole organelle. It has recently been shown experimentally that the self-assembly of SAS-6 rings is st ...

AIP Publishing2023

How Words Move Hearts: Interpretable Machine Learning Models of Bias, Engagement, and Influence in Socio-Political Systems

Aswin Suresh

We study socio-political systems in representative democracies. Motivated by problems that affect the proper functioning of the system, we build computational methods to answer research questions regarding the phenomena occurring in them. For each phenomen ...

EPFL2023

Dynamic Linkers Are the Narrow Waist of Operating Systems

Adrien Ghosn, Charly Nicolas Lucien Castes

While software applications, programming languages, and hardware have changed, operating systems have not. Widely-used commodity operating systems are still modeled after the ones designed in the seventies. The accumulated burden of backward compatibility ...

Association for Computing Machinery2023

The Case for Performance Interfaces for Hardware Accelerators

George Candea, Rishabh Ramesh Iyer, Jiacheng Ma, Aikaterini Argyraki

While systems designers are increasingly turning to hardware accelerators for performance gains, realizing these gains is painstaking and error-prone. It can take several person-months to determine if a given accelerator is a good fit for a given piece of ...

2023

Remote wide angle view broad wavelength viewing system compatible with D-T operations in JET

Gilles Arnoux, Paulo Giovane Paschoali Pereira Puglia

Imaging diagnostics in Joint European Torus have become essential in the study of plasma wall interactions and the protection of the plasma facing components. During deuterium operations, the location of these diagnostics was at close proximity to the vess ...

2023

Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro

Hilal Lashuel, Yllza Jasiqi, Lixin Yang

TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberrant misfolding or ...

Amer Chemical Soc2023

Principles of checkpoint override

Ahmad Sadeghi

Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...

EPFL2022

Misplaced Trust and Distrust: How Not to Engage with Medical Artificial Intelligence

Marcello Ienca

Artificial intelligence (AI) plays a rapidly increasing role in clinical care. Many of these systems, for instance, deep learning-based applications using multilayered Artificial Neural Nets, exhibit epistemic opacity in the sense that they preclude compre ...

CAMBRIDGE UNIV PRESS2022

Design of experiments to investigate multi-additive cellulose nanocrystal films

Tiffany Abitbol

Cellulose nanocrystal (CNC) suspensions can self-assemble into chiral nematic films upon the slow evaporation of water. These films are brittle, as indicated by their fracturing instead of plastically deforming once they are fully elastically deformed. Thi ...

FRONTIERS MEDIA SA2022

Code Generation Approach Supporting Complex System Modeling based on Graph Pattern Matching

Dimitrios Kyritsis, Yan Yan, Jinzhi Lu

Code generation is an effective way to drive the complex system development in model-based systems engineering. Currently, different code generators are developed for different modeling languages to deal with the development of systems with multi-domain. T ...

ELSEVIER2022

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Grand canonical Brownian dynamics simulations of adsorption and self-assembly of SAS-6 rings on a surface

Pierre Gönczy, Niccolo Banterle

AIP Publishing2023

How Words Move Hearts: Interpretable Machine Learning Models of Bias, Engagement, and Influence in Socio-Political Systems

Aswin Suresh

EPFL2023

The Case for Performance Interfaces for Hardware Accelerators

George Candea, Rishabh Ramesh Iyer, Jiacheng Ma, Aikaterini Argyraki

2023

Dynamic Linkers Are the Narrow Waist of Operating Systems

Adrien Ghosn, Charly Nicolas Lucien Castes

Association for Computing Machinery2023

Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro

Hilal Lashuel, Yllza Jasiqi, Lixin Yang

Amer Chemical Soc2023