The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies
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Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...
Signals detected with functional brain imaging techniques are based on the coupling between neuronal activity and energy metabolism. Positron emission tomography signals detect blood flow, oxygen consumption and glucose utilization associated with neuronal ...
A tight coupling exists between neuronal activity and energy metabolism. Over a century ago Roy and Sherrington postulated that “the brain possesses intrinsic mechanisms by which its vascular supply can be varied locally in correspondence with local variat ...
The aim of this study is to obtain voxel-by-voxel images of binding parameters between [11C]-Flumazenil and benzodiazepine receptors using positron emission tomography (PET). We estimate five local parameters (k1, k2, B'max, kon/VR, koff) by fitting a thre ...
Astrocyte end-feet surround intraparenchymal microvessels and represent therefore the first cellular barrier for glucose entering the brain. As such, they are a likely site of prevalent glucose uptake. Astrocytic processes are also wrapped around synaptic ...
Background. We describe a set of image processing algorithms and mathematical models that can be advantageously used in schemes for the segmentation of thallium-201-single photon emission computed tomography (SPECT) images and for computation of left ventr ...
Recent instrumentation advances have made it possible to apply experimental synchrotron radiation techniques of materials science to biophysics problems. We present the first results of a systematic photoelectron spectromicroscopy study of the interaction ...
EXPERIMENTAL evidence of the preferential uptake of aluminium by GABAergic neurones and glial cells was provided by synchrotron spectromicroscopy studies. We observed rat cerebellar cultures enriched for GABAergic neurones or glial cells exposed to alumini ...
The transport of lactate is an essential part of the concept of metabolic coupling between neurons and glia. Lactate transport in primary cultures of astroglial cells was shown to be mediated by a single saturable transport system with a Km value for lacta ...
