Publication

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

Publications associées (167)

Fetal Epiphyseal Chondrocytes Behavior within 3D Hydrogels

Philippe Abdel Sayed, Azadeh Khoushabi, Salim Elias Darwiche

Of the many external factors that affect cell behavior, mechanical cues have been found to be fundamental in modulating a cell’s phenotype. Indeed, merely changing substrate stiffness in monolayer culture systems generates drastically different phenotypes ...

2011

Bone regeneration and stem cells

Dominique Pioletti

This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, e ...

2011

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Jeffrey Alan Hubbell

We present use of a synthetic, injectable matrix metalloproteinase (MMP)- responsive, bioactive hydrogel as an in situ forming scaffold to deliver thymosin beta 4 (T beta 4), a pro-angiogenic and pro-survival factor, along with vascular cells derived from ...

2011

Targeting of multiple metabolites in neural cells monitored by using protein-based carbon nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero, Giovanna Del Vecchio

Microdevices dedicated to monitor metabolite levels have recently enabled many applications in the field of cell analysis, to monitor cell growth and development of numerous cell lines. By combining the traditional technology used for electrochemical biose ...

2011

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as one of the most frequently gained/amplified genomic sites in SCC of various t ...

Public Library of Science2010

Functional analysis and knock‐down phenotype of BCL9 and BCL9L in cancer cell lines

Fanny Bringolf

Therapy‐resistant tumor cells often display EMT and stem cell‐like traits. The canonical Wnt pathway has been associated with these phenotypes in many cancer types. Our group has shown in mice that two proteins of this pathway, Bcl9 and Bcl9l, participate ...

2010

High-throughput methods to define complex stem cell niches

Matthias Lütolf, Stefan Kobel

The potential of stem cells in clinics and as a diagnostic tool is still largely unmet, partially due to a lack of in vitro models that efficiently mimic the in vivo stem cell microenvironment—or niche—and thus would allow reproducible propagation of stem ...

2010

Improved viability of freeze-thawed embryonic stem cells after exposure to glutathione

Seung Tae Lee

Adding a potent antioxidant, glutathione (GSH), to a cryoprotective solution consisting of dimethyl sulfoxide and ethylene glycol and/or postthaw culture medium significantly improved the postthaw viability of mouse embryonic stem cells. This effect, which ...

2010

Embryonic stem cell-like cells established by culture of adult ovarian cells in mice

Seung Tae Lee

Objective: To suggest an alternative strategy for deriving histocompatible stems cells without undertaking genetic manipulation. ...

2010

Optimization of microfluidic single cell trapping for long-term on-chip culture

Philippe Renaud, Matthias Lütolf, Ana Valero, Stefan Kobel, Jonas Marcel Lätt

The poor efficiency of microfluidic single cell trapping is currently restricting the full potential of state-of-the-art single cell analyses. Using fluid dynamics simulations in combination with particle image velocimetry to systematically optimize trap a ...

Royal Society of Chemistry2010

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