In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds
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BACKGROUND: A theoretical model and an experimental setup were specifically designed to identify and determine the delay of the cortical bone response (restricted to mineralization and demineralization) to a stress change. METHODS: The in vivo experiment c ...
Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...
CONTEXT: Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action. ...
Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...
The mechanical properties of healthy and diseased bone tissue were extensively studied in mechanical tests. Most of this research was motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged ...
Motivated by applications in orthopaedic surgery, new constitutive laws for trabecular (or spongious) bone are developed in the framework of continuum mechanics, implemented in a mechanical analysis computer program, validated by a number of in vitro exper ...
Injectable calcium phosphate hydraulic cement (CPHC) is a new bone substitute family. This study aimed to evaluate the use of CPHC in surgical periodontitis-simulating defects in a dog model. CPHC was obtained by adding powder mixtures of different calcium ...
Particles generated from orthopedic implants through years of wear play an essential role in the aseptic loosening of a prosthesis. We have investigated the biocompatibility of these orthopedic particles on different osteoblast-like cells representative of ...
