Effects of morphogen advection on osteogenic differentiation of hMSCs using a microfluidic device with 2D micro patterned cell colonies
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The goal of this study is to analyze mechanical behavior of a new scaffold composed of PLA/bTCP in revision knee arhtroplasty (RKA). For this purpose, finite element models of RKA was developed to study the importance of the geometry of bones, the fixation ...
Protrusion, the first step of cell migration, is driven by actin polymerization coupled to adhesion at the cell's leading edge. Polymerization and adhesive forces have been estimated, but the net protrusion force has not been measured accurately. We arrest ...
Interstitial fluid flow has been shown to affect the organization and behavior of cells in 3D environments in vivo and in vitro, yet the forces driving such responses are not clear. Due to the complex architecture of the extracellular matrix (ECM) and the ...
μmotion affects the peri-implant bone formation . However, no experimental method to measure 3D μmotion along the peri-implant surface has been developed so far, besides uniaxial μmotion in a limited number of sites [2]. This work consists in devising an e ...
We present a technology for the fabrication of three dimensional microfluidic channels in optically transparent substrates consisting of polymers with different properties. The microstructures are fabricated using polymer replication techniques with a view ...
Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of tissues. To investigate these roles and exploit them for tissue engineering or to overcome barriers to drug delivery, a comprehensive consideration of the interstit ...
A dosage system for feeding a fluid (A) to a static mixer (1), said system comprising a tank (2) containing said fluid (A) at a predetermined pressure, a fluid passage (3) connecting said container (1) and tank (2), a control valve (4) provided within said ...
The invention relates to an apparatus for performing chemical assays in an aqueous medium. The apparatus contains a reaction chamber(s) and a liquid in-flow channel connected to each chamber. The flow of liquid through the fluid in-flow channel to the reac ...
Micromotion affects the tissue outcome at the peri-implant site. Interstitial fluid flow, induced by micromotion, may play a curtail part in the mesenchymal stem cell differentiation pathway necessary for bone regeneration. The aim of this project is to mo ...
Synthetic bone substitutes are potentially the future gold standard in orthopaedic and traumatologic surgery. The availability of these bone substitutes with different biomechanical properties may well replace autografts in the future as they overcome comp ...