Publication
Establishment of polarized microglial cells derived from mouse embryonic stem cells
Publications associées (192)
Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques
Heinrich Hofmann, Alke Fink, Benedikt Steitz
Introduction: Superparamagnetic iron oxide nanoparticles (SPIONs) have been successfully used for magnetic resonance imaging (MRI) of atherosclerotic plaques. Endocytosis into monocytes/macrophages has been proposed as the mechanism for SPION uptake, but a ...
2007IL-13 induces expression of CD36 in human monocytes through PPARgamma activation
The class B scavenger receptor CD36 is a component of the pattern recognition receptors on monocytes that recognizes a variety of molecules. CD36 expression in monocytes depends on exposure to soluble mediators. We demonstrate here that CD36 expression is ...
2007Interaction of Functionalized Superparamagnetic Iron Oxide Nanoparticles with Brain Structures
Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) com-bined with magnetic resonance imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative diseases. A major improvement would be to link therapeutic drugs to the SPIONs to a ...
2006Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation
Nicola Harris, Benjamin John Marsland
Nuclear factor of activated T (NFAT) cells is a family of transcription factors important for the regulation of cytokine expression by CD4+ T cells. Whilst a number of studies have examined NFAT activity of in vitro generated CD4+ T helper (Th)1 and Th2 ce ...
2006Photodynamic therapy as a novel therapeutic approach for the treatment of Crohn's disease
Hubert van den Bergh, Georges Wagnières, Dominique Velin
Photodynamic therapy (PDT) may modify the mucosal immune response and thus serve as a therapy for Crohn’s disease (CD). After evaluating safety in BALB/c mice and establishing an endoscopic index of colitis (EIC), we could demonstrate that a single «low do ...
2006c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis
A subset of CD8 T cells in normal mice, expressing high levels of activation markers such as CD44, shares many properties with antigen-specific memory CD8 T cells. Homeostasis of CD44(high) CD8 T cells depends upon cytokines such as interleukin-15 (IL-15); ...
2006Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Laure Gurcel
Many pathogenic organisms produce pore-forming toxins as virulence factors. Target cells however mount a response to such membrane damage. Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium, which promote ...
2006PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse
BACKGROUND: Inflammation is a hallmark of acute lung injury and chronic airway diseases. In chronic airway diseases, it is associated with profound tissue remodeling. Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a ligand-activated transc ...
2005Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
Chicory is a major source of fructans with reported prebiotic-bifidogenic properties. In the present study, the potential anti-inflammatory activities of chicory were investigated. Ethyl acetate chicory root extract produced a marked inhibition of prostagl ...
Elsevier2005Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells
Nicola Harris, Benjamin John Marsland
CD8+ memory T cells have recently been recognized as playing a key role in natural immunity against unrelated viral infections, a phenomenon referred to as "heterologous antiviral immunity." We now provide data that the cellular immunological interactions ...
2004