One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition
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Contextual information is important for sequence modeling. Hidden Markov Models (HMMs) and extensions, which have been widely used for sequence modeling, make simplifying, often unrealistic assumptions on the conditional independence of observations given ...
Chloroethenes, and most particularly tetra- (PCE) and trichloroethene (TCE) are major groundwater pollutants due to their extensive industrial use as solvents since the 1920s. The strong electronegativity of the chlorines renders them very stable under aer ...
Contextual information is important for sequence modeling. Hidden Markov Models (HMMs) and extensions, which have been widely used for sequence modeling, make simplifying, often unrealistic assumptions on the conditional independence of observations given ...
The sequence profile method (Gribskov M, McLachlan AD, Eisenberg D, 1987, Proc Natl Acad Sci USA 84:4355-4358) is a powerful tool to detect distant relationships between amino acid sequences. A profile is a table of position-specific scores and gap penalti ...
Accurate prediction of transcription factor binding sites is needed to unravel the function and regulation of genes discovered in genome sequencing projects. To evaluate current computer prediction tools, we have begun a systematic study of the sequence-sp ...
We present a probabilistic interpretation of local sequence alignment methods where the alignment scoring system (ASS) plays the role of a stochastic process defining a probability distribution over all sequence pairs. An explicit algorithms is given to co ...
Optimized weight matrices defining four major eukaryotic promoter elements, the TATA-box, cap signal, CCAAT-, and GC-box, are presented; they were derived by comparative sequence analysis of 502 unrelated RNA polymerase II promoter regions. The new TATA-bo ...