The asym. synthesis of two appropriately functionalized nonproteinogenic amino acids I (Troc = CO2CH2CCl3, TBS = SiMe2CMe3) and II (Boc = Me3CO2C) needed for the total synthesis of vancomycin is described. The assemblage of these amino acids into linear tripeptide followed by biaryl ether formation via intramol. SNAr reaction led to the fully functionalized C-O-D ring III of vancomycin. [on SciFinder (R)]
Jérôme Waser, Eliott Hugo Joran Le Du, Marion Marie-Agnès Garreau
Tamar Kohn, Aleksandar Antanasijevic, Kiruthika Kumar, Shotaro Torii
Pablo Rivera Fuentes, Salome Riccarda Püntener