Synthesis of D- and L-erythro 1,5-dithiopent-1-enopyranoside sulfonium salts and their evaluation as glycosidase inhibitors
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A -75 DegC, alpha-lithiated allyl Ph ether undergoes mainly the Wittig rearrangement to afford, after acidic hydrolysis, 1-phenyl-2-propen-1-ol as the main product. A second metalation taking place at one of the ortho positions is the sole competing side r ...
The invention relates to the prepn. of esters R1R2NCH2CH(Nu)CO2R3 (R1-R3 are protecting groups and Nu is a nucleophilic group) by reaction of R1R2NCH(CH2-Y)CO2R3 (Y is a leaving group) with a nucleophile. Thus, treatment of (R)-Bn2NCH(CH2O3SMe)CO2Me with N ...
Atmospheric trace gases and aerosols and climate interact in many ways. A quantitative assessment of the influence of trace gases and aerosols on climate can only be achieved if the interactions and feedbacks among these three major components are accounte ...
Recently, a novel metal Mg2+-dependent phosphatase activity has been discovered in the N-terminal domain of the soluble epoxide hydrolase (sEH), opening a new branch of fatty acid metabolism and providing an additional site for drug targeting. Importantly, ...
N,N-Bis(diphenylphosphino)ethylaniline compounds, Ph2PN-C6H4-C2H5, with ethyl groups at the ortho- and para-positions have been synthesized. Oxidation of the aminophosphines with hydrogen peroxide, elemental sulfur and selenium gave the corresponding ...
Profiles of the major sulfur functional groups in mature Norway spruce wood tissue have been established for the first time. The big challenge was the development of a method suitable for sulfur speciation in samples with very low sulfur content (
The first ene reactions of SO2 and unfunctionalized alkenes are reported. Calculations suggest that the endergonic ene reactions of SO2 with alkenes can be used to generate beta,gamma-unsaturated sulfinyl and sulfonyl compounds. Indeed, in the presence of ...
Bio synthetic natural gas (Bio-SNG) is being proposed as an alternative to the natural gas of fossil origin (NG) [1]. Bio-SNG consists mainly of CH4 (at least 95%mol), has a high heating value (e.g. 10 kWh/m3N), and respects the quality standards of the NG ...
An efficient synthesis of chiral dihydrooxazines from 1-aryl-2-amino-propane-1,3-diols via the corresponding bistrichloroacetimidate intermediates has been developed. In this transformation, one trichloroacetimidate acts as a leaving group and the other ac ...
We study the influence of Sr substitutions on the structural counterpart of the MI transition of BaVS3. When Sr content increases, the commensurate CDW modulation of pure BaVS3 is changed into an incommensurate short range modulation that we attribute to a ...