Differential neuroglycan C expression during retinal degeneration in Rpe65(-/-) mice

Pascal Escher
2008
Article

Résumé

Purpose: An increased mRNA expression of the genes coding for the extracellular matrix proteins neuroglycan C (NGC), interphotoreceptor matrix proteoglycan 2 (IMPG2), and CD44 antigen (CD44) has been observed during retinal degeneration in mice with a targeted disruption of the Rpe65 gene (Rpe65(-/-) mouse). To validate these data, we analyzed this differential expression in more detail by characterizing retinal NGC mRNA isoform and protein expression during disease progression.

Source officielle

https://infoscience.epfl.ch/record/160270?ln=fr

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Differential neuroglycan C expression during retinal degeneration in Rpe65(-/-) mice

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Statistical learning quantifies transposable element-mediated cis-regulation

Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs