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Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Publications associées (53)

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Microvascular stalling, the process occurring when a capillary temporarily loses perfusion, has gained increasing interest in recent years through its demonstrated presence in various neuropathologies. Studying the impact of such stalls on the surrounding ...

2023

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Lydia Aslanidou, Fotios Savvopoulos

Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed sh ...

ELSEVIER SCI LTD2021

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Johan Auwerx

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondri ...

2020

The effect of Landau damping is often calculated based on a Gaussian beam distribution in all degrees of freedom. The stability of the beam is however strongly dependent on the details of the distribution. The present study focuses on the change of bunch d ...

IOP PUBLISHING LTD2019

Lightning Location Systems and Interstroke Intervals: Effects of Imperfect Detection Efficiency

Marcos Rubinstein, Mohammad Azadifar, Mirjana Stojilovic

Lightning location systems (LLSs) are often used to obtain parameters of lightning flashes. However, the imperfect detection efficiency (DE) of these systems affects the accuracy of the results. In this paper, we focus on the effects of the imperfect DE on ...

Ieee2016

Surface Turbulence on Bores and Surges propagating on Smooth and Rough Beds

Anton Schleiss, Michael Pfister, Pedro Filipe De Almeida Manso, Davide Wüthrich

Hydrodynamic waves are characterised by unsteady, highly turbulent and irregular behaviours. In nature, such phenomena can be observed in dam breaks, impulse waves and tsunamis. Both wet bed bores and dry bed surges were experimentally reproduced on smooth ...

2016

We report on the real space profile of spin polarons in the quasi-two-dimensional frustrated dimer spin system SrCu2(BO3)(2) doped with 0.16% of Zn. The B-11 nuclear magnetic resonance spectrum exhibits 15 additional boron sites near nonmagnetic Zn impurit ...

2015

We revisit the concept of marginal stability in glasses and determine its range of applicability in the context of an avalanche-type response to slow external driving. We argue that there is an intimate connection between a pseudogap in the distribution of ...

2015

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Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell biology. In blood vessels, disturbed flow is associated with vascular diseases, such as atherosclerosis, and promotes endothelial cell proliferation and apoptosis ...

American Society for Clinical Investigation2015

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Patrick Aebischer, Bernard Schneider, Wojciech Janusz Bobela

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects ...

Mdpi Ag2015