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Three-Dimensional Magnetic Focusing of Superparamagnetic Beads for On-Chip Agglutination Assays

Publications associées (36)

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Capillary Microfluidic Chips for Point-of-Care Testing

Luc Gervais

Research on microfluidic devices for biological analysis has progressed sufficiently to be developed into point-of-care diagnostics products. The goal of this thesis is to improve multiple aspects of capillary-driven microfluidic devices. In particular, th ...

EPFL2011

Optical Trapping in Microfluidic Channels for Functional and Chemical Analysis of Single Cells

Michael Werner

The physiological properties of cells are typically investigated in ensembles yielding averaged data that mask heterogeneities present in any cell population. Single-cell analysis techniques based on microfluidic "lab on a chip" (LOC) devices have recently ...

EPFL2011

Dynamic Actuation of Magnetic Beads for Immunoassays on-chip

Yves Moser

This thesis was carried out in the frame of the European project DetectHIV aiming the development of a new biosensor platform for the highly sensitive detection of the HIV capsid protein p24. We explore the implementation of a magnetic bead-based lab-on-a- ...

EPFL2010

We present techniques and methodologies for the manipulation of magnetic micro- and nanoparticles ('beads') in microfluidic systems. We first introduce the most important forces that act on magnetic particles in a microfluidic system. Starting with the mag ...

Springer, 101 Philip Drive, Norwell, Ma 02061 Usa2010

Microfluidic Immunoassays Based on Self-Assembled Magnetic Bead Patterns and Time-Resolved Luminescence Detection

Venkataragavalu Sivagnanam

Microfluidic bio-assays have emerged as the most privileged solutions and provide the basis for the realization of miniaturized bio-analytical systems and clinical diagnostic devices that are portable, user-friendly and cost-effective (Lab-on-a-chip). Two ...

EPFL2010

3-dimensional electrode patterning within a microfluidic channel using metal ion implantation

Demetri Psaltis, Herbert Shea, Samuel Rosset, Muhamed Niklaus, Jae-Woo Choi, James Adleman

The application of electrical fields within a microfluidic channel enables many forms of manipulation necessary for lab-on-a-chip devices. Patterning electrodes inside the microfluidic channel generally requires multi-step optical lithography. Here, we uti ...

Royal Society of Chemistry2010

Magneto-microfluidic three-dimensional focusing of magnetic particles

Martinus Gijs, Thomas Lehnert, Yves Moser, Rana Afshar Ghasemlouy

We present a method for magneto-microfluidic three-dimensional focusing of magnetic microparticles from a dense plug into a single streamline with longitudinal inter-particle spacing. Plug formation on-chip is induced by a high-gradient magnetic field gene ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2010

Quadrupolar magnetic actuation of superparamagnetic particles for enhanced microfluidic perfusion

Martinus Gijs, Thomas Lehnert, Yves Moser

We report on the magnetic actuation of superparamagnetic particles in a microfluidic channel. The formation of a highly confined and dynamic plug of particles extending over the cross section of the microchannel is enabled by superposing a static and a tim ...

2009

Magnetic microparticles and their application in bioanalytical microfluidic systems have been steadily gaining interest in recent years. This progress is fueled by the comparatively large and long range magnetic forces that can be obtained independently of ...

EPFL2008

Magnetohydrodynamic pumping in nuclear magnetic resonance environments

Nico de Rooij

We present a DC magnetohydrodynamic (MHD) pump as component of a nuclear magnetic resonance (NMR) microfluidic chip. This is the first time that MHD pumping in an NMR environment was observed and demonstrated. This chip generates a maximum flow rate of 1.5 ...

2007