LeukoplakiaOral leukoplakia is a potentially malignant disorder affecting the oral mucosa. It is defined as "essentially an oral mucosal white lesion that cannot be considered as any other definable lesion." Oral leukoplakia is a white patch or plaque that develops in the oral cavity and is strongly associated with smoking. Leukoplakia is a firmly attached white patch on a mucous membrane which is associated with increased risk of cancer. The edges of the lesion are typically abrupt and the lesion changes with time.
Selective estrogen receptor modulatorSelective estrogen receptor modulators (SERMs), also known as estrogen receptor agonist/antagonists (ERAAs), are a class of drugs that act on the estrogen receptor (ER). A characteristic that distinguishes these substances from pure ER agonists and antagonists (that is, full agonists and silent antagonists) is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues.
Lame basalevignette|droite|Lame basale observée en microscopie électronique en transmission. La lame basale est un assemblage de protéines et glycoprotéines extracellulaires sur lequel reposent les cellules épithéliales et aussi les cellules musculaires. Elle permet l'adhérence de la cellule épithéliale au tissu conjonctif sous-jacent et constitue une interface majeure entre les cellules du tissu épithélial et l'intérieur de l'organisme, pour la régulation et la diffusion des nutriments.
Transitional epitheliumTransitional epithelium is a type of stratified epithelium. Transitional epithelium is a type of tissue that changes shape in response to stretching (stretchable epithelium). The transitional epithelium usually appears cuboidal when relaxed and squamous when stretched. This tissue consists of multiple layers of epithelial cells which can contract and expand in order to adapt to the degree of distension needed. Transitional epithelium lines the organs of the urinary system and is known here as urothelium (: urothelia).
Bioéquivalencevignette|Budeprion xl et Wellbutrin introduit à la bioequivalence La bioéquivalence ou bio-équivalence est un terme de pharmacologie. Deux principes actifs sont dits bioéquivalents lorsque, administrés à la même concentration, ils engendrent normalement les mêmes effets. La biodisponibilité : correspond à la fraction de substance administrée par voie autre qu'intraveineuse qui sera retrouvée effectivement dans la circulation. Aptitude d'un principe actif à atteindre son ou ses sites d'action sous forme inchangée ou sous forme de métabolites actifs selon une cinétique déterminée.
Principal (commercial law)In commercial law, a principal is a person, legal or natural, who authorizes an agent to act to create one or more legal relationships with a third party. This branch of law is called agency and relies on the common law proposition qui facit per alium, facit per se (from Latin: "he who acts through another, acts personally"). It is a parallel concept to vicarious liability (in which one person is held liable for the acts or omissions of another) in criminal law or torts.
