Publication

Carbon Monoxide-Releasing Micelles for Immunotherapy

Publications associées (40)

Rapid Access to Polyfunctional Lipids with Complex Architecture via Oxyanionic Ring-Opening Polymerization

Polymer-coated liposomes, particularly poly(ethylene glycol) (PEG)-substituted liposomes, have emerged as long-circulating carrier systems for drug delivery and diagnostic purposes. A rapid synthesis of three different types of multifunctional lipids with ...

American Chemical Society2011

From an Epoxide Monomer Toolkit to Functional PEG Copolymers With Adjustable LCST Behavior

Frederik Roman Wurm

The lower critical solution temperature (LCST) behavior of novel poly(ethylene glycol) (PEG)-based copolymers bearing multiple functional groups, obtained by anionic ring-opening (co)polymerization (AROP), has been investigated. Variable comonomer ratios o ...

2011

"Functional Poly(ethylene glycol)": PEG-Based Random Copolymers with 1,2-Diol Side Chains and Terminal Amino Functionality

Frederik Roman Wurm

A series of poly(ethylene glycol-co-isopropylidene glyceryl glycidyl ether) (P(EO-co-IGG)) random copolymers with different fractions of 1,2-isopropylidene glyceryl glycidyl ether (IGG) units was synthesized. After acidic hydrolysis a new type of "function ...

2010

Assessing the Role of Poly(ethylehe glycol-bl-propylene sulfide) (PEG-PPS) Block Copolymers in the Preparation of Carbon Nanotube Biocompatible Dispersions

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil

Amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG) have been used to solubilize and disperse single-walled carbon nanotubes (SWNTs). The obtained highly conc ...

2010

Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution

Jeffrey Alan Hubbell, Conlin O'Neil, Jacques Dubochet

Block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS) have recently emerged as a new macromolecular amphiphile capable of forming a wide range of morphologies when dispersed in water. To understand better the relationship between s ...

2009

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil, Andrija Finka

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Degradable Polymer Brushes Prepared via Surface-Initiated Controlled Radical Polymerization

Harm-Anton Klok, Nicolas Bertrand Schüwer, Carl Riachi

Hydrolytically degradable polymer brushes would represent an interesting platform for the development of functional coatings for various biomaterials applications In this manuscript, the surface- initiated atom transfer radical copolymerization of 5.6-benz ...

2009

Extracellular matrix binding mixed micelles for drug delivery applications

Davide Demurtas, Jeffrey Alan Hubbell, Jutta Christine Wandrey

Received 5 January 2009 Accepted 22 March 2009 Available online 27 March 2009 Keywords: Mixed micelles Drug delivery Block copolymers Sirolimus Extracellular matrix We present the formation of collagen-binding mixed micelles and their potential suitability ...

2009

Experimentally Facile Controlled Polymerization of N-Carboxyan hydrides (NCAs), Including O-Benzyl-L-threonine NCA

Matthew Gibson

It is demonstrated here that three different alpha-amino N-carboxyanhydrides (NCAs), including for the first time O-benzyl-L-threonine NCA, can be polymerized in a controlled/"living" fashion without the need for transition metal catalysts or complex custo ...

2009

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

Conlin O'Neil

Block copolymers are comprised of repeating chemical groups (blocks) which commonly contain at least one hydrophilic block coupled to at least one hydrophobic block, forming an amphipathic macromolecule. This molecular arrangement drives the self assembly ...

EPFL2008

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