Role of proteins in the controlling selenium nanoparticle size
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Regulation of gene expression is essential for the functioning of all eukaryotic organisms. Understanding gene expression regulation requires determining which proteins interact with regulatory elements in chromatin. MS-based analysis of chromatin has emer ...
The sheer size of the protein sequence space is massive: a protein of 100 residues can have 20^100 possible sequence combinations; and knowing that this exceeds the number of atoms in the universe, the chance of randomly discovering a stable new sequence w ...
Background: Large-scale proteomic studies have to deal with unwanted variability, especially when samples originate from different centers and multiple analytical batches are needed. Such variability is typically added throughout all the steps of a clinica ...
The characterization of biological interfaces is widely recognized as one of the main challenges for modern biology. In particular, biological membranes are nowadays known to be an active environment that allows membrane proteins to perform their work and ...
We study the phenomenon of intransitivity in models of dice and voting. First, we follow a recent thread of research for n-sided dice with pairwise ordering induced by the probability, relative to 1/2, that a throw from one die is higher than the other. We ...
The generation of wide-angle diffraction patterns can be done in different ways using either thin diffractive optical elements with small features sizes or arrays of microoptics with large optical paths that are thick diffractive optical elements. Our aim ...
Surface patterning using plasmonic nanoparticles has attracted increasing interest owing to their wide use in sensing, imaging and medical applications. In this report we demonstrate bottom-up engineering of size distribution of gold nanoparticles (AuNPs) ...
Cells need to reliably control their proteome composition to maintain homeostasis and regulate growth. How protein synthesis and degradation interplay to control protein expression levels remains unclear. Here, we combined a tandem fluorescent timer and pu ...
A compelling link is emerging between the posttranslational modification O-GlcNAc and protein aggregation. A prime example is alpha-synuclein, which forms toxic aggregates that are associated with neurodegeneration in Parkinson's and related diseases. alph ...
This work studies the robustness certification problem of neural network models, which aims to find certified adversary-free regions as large as possible around data points. In contrast to the existing approaches that seek regions bounded uniformly along a ...