Publication
Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
Publications associées (32)
Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation
Jacques Fellay, Bruno Emanuel Ferreira De Sousa Correia, Zhi Ming Xu, Andreas Scheck, Dylan Lawless, Olivier Noël Marie Naret, Arne Schneuing, David Gfeller, Thomas Junier, Sina Rüeger
Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host -induced selective pressure. Leveraging paired human exome and ultra -deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we ...
Cell Press2024Inborn errors of type I interferon immunity in patients with symptomatic acute hepatitis E
Background and Aims:The clinical spectrum of human infection by HEV ranges from asymptomatic to severe acute hepatitis. Furthermore, HEV can cause diverse neurological manifestations, especially Parsonage-Turner syndrome. Here, we used a large-scale human ...
Philadelphia2023Host-Pathogen Interactions Through the Genomic Lens
Hosts and pathogens are involved in a long-standing evolutionary arms race characterized by successive rounds of evolution. Specifically, while hosts evolve resistance against infections, pathogens adapt to re-establish virulence. Since the signatures of t ...
EPFL2023Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus
Hepatitis B virus remains a major medical burden with more than 250 million chronically infected patients worldwide and 900,000 deaths each year, due to the disease progression towards severe complications (cirrhosis, hepatocellular carcinoma). Despite the ...
ELSEVIER2023Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study
Torque teno virus (TTV) is considered to be an ubiquitous member of the commensal human blood virome commonly reported in mixed genotype co-infections. This study investigates the genomic diversity of TTV in blood samples from 816 febrile Tanzanian childre ...
MDPI2022Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes
Jacques Fellay, Nimisha Chaturvedi
Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...
ELIFE SCIENCES PUBLICATIONS LTD2019Population density and water balance influence the global occurrence of hepatitis E epidemics
Stéphane Joost, Anna Carratala Ripolles
In developing countries, the waterborne transmission of hepatitis E virus (HEV), caused by HEV genotypes 1 (HEV-1) and 2 (HEV-2), leads to the onset of large recurrent outbreaks. HEV infections are of particular concern among pregnant women, due to very hi ...
2019Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients
Jacques Fellay, Christian Hammer, Nimisha Chaturvedi, Petar Scepanovic, Samira Asgari
Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...
2019Population density and water balance influence the global occurrence of hepatitis E epidemics
Stéphane Joost, Anna Carratala Ripolles
In developing countries, the waterborne transmission of hepatitis E virus (HEV), particularly the genotypes 1 and 2, leads to the onset of large recurrent outbreaks. In order to identify the geographical regions at higher risk of HEV epidemics and the cond ...
2018Integration of the role of climate in the spatial modeling of waterborne hepatitis E virus
Stéphane Joost, Anna Carratala Ripolles
Hepatitis E virus (HEV) is among the major causes of acute viral hepatitis worldwide. In developing countries, HEV infections are caused by genotypes 1 and 2, due to consumption of contaminated water. Large and recurrent outbreaks of HEV occur in specific ...
2017