Publication

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Publications associées (32)

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search

Experimental strategies for studying transcription factor-DNA binding specificities

Sebastian Maerkl, Marcel Geertz

Specific binding of transcription factors (TFs) determines in a large part the connectivity of gene regulatory networks as well as the quantitative level of gene expression. A multiplicity of both experimental and computational methods is currently used to ...

2010

Prediction of Survival and Risk Assessment Using Joint Analysis of Microarray Gene Expression Data

Haleh Yasrebi

Gene expression profiles have been widely used in molecular classification, diagnosis and prediction, particularly in the area of oncology where accurate and early diagnosis is needed for appropriate treatment. Avoiding under-/over-treatment when it is not ...

EPFL2010

Computational Probability for Systems Biology

Stochastic models of biological networks properly take the randomness of molecular dynamics in living cells into account. Numerical solution approaches inspired by computational methods from applied probability can efficiently yield accurate results and ha ...

Springer2008

Gene expression profiling of two distinct neuronal populations in the rodent spinal cord

Jesper Ryge

BACKGROUND: In the field of neuroscience microarray gene expression profiles on anatomically defined brain structures are being used increasingly to study both normal brain functions as well as pathological states. Fluorescent tracing techniques in brain t ...

Public Library of Science2008

Computational Identification of MicroRNAs and Their Targets

Giovanni De Micheli

One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) forma class of endogenous 19–23-nucleotide RNAs that can have im ...

Wiley-Blackwell2006

Bioimaging and Functional Genomics

Giovanni De Micheli, Luca Benini

For better understanding of genetic mechanisms underlying clinical observations, it is interesting to determine which genes and clinical traits are interrelated. In the last few years a consistent amount of research in genomics has been done concerning cor ...

2006

Mining gene sets for measuring similarities

Giovanni De Micheli, Luca Benini

In recent years, the development of high throughput devices for the massive parallel analyses of genomic data has lead to the generation of large amount of new biological evidences and has triggered the proliferation of data mining algorithms for the extra ...

2006

Prediction and Analysis of Human MicroRNA Regulatory Modules

Giovanni De Micheli

MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a sequence-specific manner. We propose a computational method to predict miRNA regulatory modules or groups of miRNAs and target genes that are believed to participate cooper ...

2005

Coupled atomistic and discrete dislocation plasticity

William Curtin, Ronald Earle Miller

A computational method for multiscale modeling of plasticity is presented wherein each dislocation is treated as either an atomistic or continuum entity within a single computational framework. The method divides space into atomistic and continuum regions ...

2002

Long-range heterogeneity at the 3' ends of human mRNAs

Philipp Bucher

The publication of a draft of the human genome and of large collections of transcribed sequences has made it possible to study the complex relationship between the transcriptome and the genome. In the work presented here, we have focused on mapping mRNA 3' ...

2002