Publication
Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons
Publications associées (50)
Soft multimodal neural interfaces for unravelling sensory neurological circuits
Frédéric Pierre Gérald Michoud
Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...
EPFL2019System for selective spatiotemporal stimulation of the spinal cord
Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Nikolaus Wenger
The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...
2019ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury
We recently discovered a novel role for neuregulin-1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional ...
2019Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models
Grégoire Courtine, Quentin Barraud, Claudia Kathe, Thomas Haynes Hutson, Kay Alexander Bartholdi
After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...
AMER ASSOC ADVANCEMENT SCIENCE2019Regional T-1 mapping of the whole cervical spinal cord using an optimized MP2RAGE sequence
While T1 measurements present multiple challenges (robustness, acquisition time), the recently proposed MP2RAGE sequence (magnetization-prepared two rapid acquisition gradient echoes) has opened new perspectives to characterize tissue microstructure change ...
WILEY2019Optogenetic Peripheral Nerve Immunogenicity
Optogenetic technologies have been the subject of great excitement within the scientific community for their ability to demystify complex neurophysiological pathways in the central (CNS) and peripheral nervous systems (PNS). The excitement surrounding opto ...
Nature Publishing Group2018Cortico-reticulo-spinal circuits mediate functional recovery after spinal cord contusion
After a spinal cord injury (SCI), only half of affected individuals regain voluntary control of leg movements below the level of the lesion. Anatomical, electrophysiological and imaging data revealed that even the most severe forms of SCI usually spare a s ...
EPFL2017Brain-controlled neuroprosthetic interventions to restore locomotion after contusion spinal cord injury in the rat
Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. Therapies based on electrical stimulation of the spinal cord and other locomotor areas of the Nervous System improve motor control in people with neurotrauma. Neuromodulati ...
EPFL2017Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants
Neuroprosthetic systems are designed to interface with the nervous system, for the replacement or restoration of damaged functions in the motor and/or sensory systems. In order to have an efficient communication with the nervous tissue leading to optimized ...
EPFL2017Influencing axon regeneration after spinal cord injury
Spinal cord injury (SCI) results in a severing of axonal connections that leads to permanent sensorimotor deficits. In cases of incomplete injury, rehabilitation paradigms have been reported to be successful in improving behavioral outcome in humans with S ...
EPFL2017