Chemiluminescence, i.e. the emission of light from a chemical reaction, offers interesting opportunities for developing point-of-care biosensors. However, commercially available systems are expensive, bulky, and primarily addressed to laboratory usage. The goal of this paper is to present a novel work related to the design and experimental validation of a point-of-care device for cancer marker detection in human serum. The new system has been especially developed for cost-sensitive applications using only low-cost off-the-shelf components. The system was tested with blood serum. The output signal from spots with specific proteins uptake was two orders of magnitude higher than that from control spots: it was 14 +/- 3 mV/s from the detection spots, while it was only 260 mu V/s and 242 mu V/s from the control spots. (C) 2010 Elsevier B.V. All rights reserved.
Dominique Bonvin, Julien Léo Billeter, Sriniketh Srinivasan
Ksenia Briling, Puck Elisabeth van Gerwen, Yannick Calvino Alonso, Malte Martin Franke
Andreas Züttel, Emad Oveisi, Emanuele Moioli, Kun Zhao, Robin Tobias Andreas Mutschler