Publication

An extracellular matrix protein microarray to study endothelial to mesenchymal transformation in mitral valve endothelial cells

Publications associées (45)

Capturing Cardiogenesis in Gastruloids

Matthias Lütolf, Romain Guiet, Giuliana Rossi, Andrea Boni, Nicolas Antoine Vincent Broguiere, Mehmet Ugur Girgin

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

CELL PRESS2021

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

Alfio Quarteroni

Before septation processes shape its four chambers, the embryonic heart is a straight tube that spontaneously bends and twists breaking the left-right symmetry. In particular, the heart tube is subjected to a cell remodeling inducing ventral bending and de ...

SIAM PUBLICATIONS2021

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Alfio Quarteroni, Francesco Regazzoni

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mech ...

SPRINGER SINGAPORE PTE LTD2020

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1(+) epicardial cells

Na Li

Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts related to improved neovascularis ...

ELIFE SCIENCES PUBLICATIONS LTD2020

Computational fluid dynamics of blood flow in an idealized left human heart

Alfio Quarteroni, Filippo Menghini

We construct an idealized computational model of the left human heart for the study of the blood flow dynamics in the left atrium and ventricle. We solve the Navier-Stokes equations in the ALE formulation and we prescribe the left heart wall displacement b ...

WILEY2019

Numerical approximation of cardiac electro-fluid-mechanical models

Antonello Gerbi

The mathematical modeling of the heart involves several challenges, which are intrinsically related to the complexity of its function. A satisfactory cardiac model must be able to describe a wide range of different processes, such as the evolution of the t ...

EPFL2018

Impact of individual differences in glucocorticoid adaptation to stress on behavior, neurophysiology and metabolism

Damien Sébastien Huzard

The stress system is a key modulator of homeostasis and allows organisms to adapt to environmental changes. Proper survival is dependent on the appropriate stress response, for example initiating food (energy) intake or provoking physical reaction. However ...

EPFL2018

Integrated Heart-Coupling multiscale and multiphysics models for the simulation of the cardiac function

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Toni Mikael Lassila, Simone Rossi

Mathematical modeling of the human heart and its function can expand our understanding of various cardiac diseases, which remain the most common cause of death in the developed world. Like other physiological systems, the heart can be understood as a compl ...

Elsevier Science Sa2017

Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment

Philippe Renaud

Lab-on-a-chip systems are increasingly used as tools for cultures and investigation of cardiac cells. In this article, we present how the geometry of microsystems and microenvironmental conditions (static and perfusion) influence the proliferation, morphol ...

Sage Publications Inc2017

Complex blood flow patterns in an idealized left ventricle: A numerical study

Alfio Quarteroni, Anna Tagliabue

In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We pro ...

Amer Inst Physics2017

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