k(L)a as a predictor for successful probe-independent mammalian cell bioprocesses in orbitally shaken bioreactors
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In order to investigate cell-specific differences in the response of in vitro models to environmental toxicants, we compared the capacity of nine polycyclic aromatic hydrocarbons (PAHs) to induce cytochrome P4501A (CYP1A) in primary rainbow trout (Oncorhyn ...
Society of Environmental Toxicology and Chemistry Press2001
To overcome ammonia inhibition in animal cell culture, a method utilizing porous polytetrafluoroethylene membranes with an assocd. pH gradient was investigated. Model expts. without cells were carried out in three different reactor configurations suitable ...
The docking protein Gab1 binds phosphorylated c-Met receptor tyrosine kinase directly and mediates signals of c-Met in cell culture. Gab1 is phosphorylated by c-Met and by other receptor and nonreceptor tyrosine kinases. Here, we report the functional anal ...
Methodology was developed for quantifying the photocytotoxicity of fluoranthene to a gill cell line from rainbow trout for future use in screening polycyclic aromatic hydrocarbons for their relative photocytotoxicity to fish. Solubilization in a modified c ...
A review with many refs. Ammonia has been reported to be toxic and inhibitory for mammalian cell cultures for many years. Redn. of growth rates and maximal cell densities in batch cultures, changes in metabolic rates, perturbation of protein processing and ...
