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Three-dimensional organization of gene expression in erythroid cells

Publications associées (41)

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Experimental strategies for studying transcription factor-DNA binding specificities

Sebastian Maerkl, Marcel Geertz

Specific binding of transcription factors (TFs) determines in a large part the connectivity of gene regulatory networks as well as the quantitative level of gene expression. A multiplicity of both experimental and computational methods is currently used to ...

2010

Long-range enhancer-promoter interactions in the HoxD complex

Denis Duboule

Collinear expression of 5′ Hoxd genes during mammalian limb development is required to properly determine digits number and identity. We recently proposed a two-step model to account for the underlying regulatory mechanism, which involves an initial loopin ...

Elsevier Science BV2009

Gateway-Compatible Yeast One-Hybrid Screens

Bart Deplancke

Protein-DNA interactions (PDIs) between transcription factors (TFs) and their target genes form the backbone of transcription regulatory networks. Such PDIs can be identified with either a TF or a gene as a starting point. The Gateway-compatible yeast one- ...

2006

Computational Identification of MicroRNAs and Their Targets

Giovanni De Micheli

One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) forma class of endogenous 19–23-nucleotide RNAs that can have im ...

Wiley-Blackwell2006

A gateway-compatible yeast one-hybrid system

Bart Deplancke

Since the advent of microarrays, vast amounts of gene expression data have been generated. However, these microarray data fail to reveal the transcription regulatory mechanisms that underlie differential gene expression, because the identity of the respons ...

2004

High-throughput SELEX SAGE method for quantitative modeling of transcription-factor binding sites

Philipp Bucher

The ability to determine the location and relative strength of all transcription-factor binding sites in a genome is important both for a comprehensive understanding of gene regulation and for effective promoter engineering in biotechnological applications ...

2002

Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation

Lukas Kühn

High expression of transferrin receptor (TfR) on the membrane of erythroid cells accounts for the high level of iron required to sustain heme synthesis. Several studies indicate that during erythroid differentiation TfR expression is highly dependent on tr ...

2002

Regulatory elements and expression profiles

Philipp Bucher

There has been steady progress in the computational analysis of transcription control regions, but current methods of predicting the gene regulatory features of noncoding sequences are still not accurate enough to be useful in automatic genome annotation. ...

Elsevier1999

Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements

Philipp Bucher

We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors. Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha g ...

1995

Analysis of the mouse tyrosinase promoter in vitro and in vivo

Friedrich Beermann

The restricted expression of the tyrosinase gene in cells producing pigment suggests the presence of cis-regulatory elements and trans-acting tissue-specific factors. Since 270 bp upstream of the transcriptional start site contain sufficient information fo ...

1994