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The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic ...
The ankle is a complex joint of the human body which is most often affected by trauma. Osteoarthritis is a joint disease that can require surgical intervention and when it affects the ankle there are two options to achieve pain relief. For years ankle fusi ...
Smooth muscle and endothelial cells in the arterial wall are exposed to mechanical stress. Indeed blood flow induces intraluminal pressure variations and shear stress. An increase in pressure may induce a vessel contraction, a phenomenon known as the myoge ...
Today neuromuscular simulations are used in several fields, such as diagnostics and planing of surgery, to get a deeper understanding of the musculoskeletal system. During the last year, new models and datasets have been presented which can provide us with ...
In orthopaedics, outcome evaluation is currently recognized as a major challenge to improve the knowledge both about injuries and treatments. For anterior cruciate ligament (ACL) rupture, various evaluation tools are available for routine uses: clinical ex ...
Computational models are a current way to study specific behavior of healthy or pathological tissue or the mechanics of joints. Simulating the native anatomical structures and kinematics are two of the most important tasks to achieve reliable results. It i ...
Six adult monkeys (Macaca mulatta) received a unilateral lesion of the lateral corticospinal tract (CST) in the thoracic spinal cord. Prior to surgery, the animals were trained to perform quadrupedal stepping on a treadmill, and item retrieval with the foo ...
Two surgical treatments exist for ankle osteoarthritis (AO): ankle arthrodesis (AA) and total ankle replacement (TAR). Due to advantages and drawbacks of each treatment, decision making about these treatments is still a clinical question and thus, their ou ...
The importance of evaluation of an orthopedic operation such as hip or knee arthroplasty has long been recognized. Many definitions of outcome and scoring questionnaires have been used in the past to assess the outcome of joint replacement. However, these ...
This thesis is the first to be carried out within the framework of the project "Cyberthosis for Paraplegics" in progress at the "Laboratoire de Systèmes Robotiques" (LSRO) of the "Ecole Polytechnique Fédérale de Lausanne" (EPFL). This project, initiated in ...
