Publication
Explaining the length threshold of polyglutamine aggregation
Publications associées (36)
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies
Hilal Lashuel, Pedro José Santana Ribeiro Magalhães
Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with ...
NATURE PORTFOLIO2022Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed in a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteost ...
2021Energy-Efficient Design Techniques for High-Speed Wireline Serial Links
The exponential growth in computing power and multimedia services has caused a tremendous increase in data traffic in recent years. This increase in data traffic brings a strong demand for data bandwidth of electrical input/output (I/O) links and pushes th ...
EPFL2021Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression
Bénédicte Marie Maréchal, Jonas Richiardi, Christopher Clark
BackgroundTo assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer's disease (AD) pathology and predict clinical progression in a memory clinic setting.MethodsPlasma NfL and p-ta ...
BMC2021Relative Effects of the Hospital Readmissions Reduction Program on Hospitals That Serve Poorer Patients
Importance: Hospitals that serve poorer populations have higher readmission rates. It is unknown whether these hospitals effectively lowered readmission rates in response to the Hospital Readmissions Reduction Program (HRRP). Objective: To compare pre-post ...
2019Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development
Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are the two most common motoneuron disorders, which share typical pathological hallmarks while remaining genetically distinct. Indeed, SMA is caused by deletions or mutations in the surv ...
ELSEVIER SCIENCE BV2018Comparison of linear frequency and amplitude modulation for intraneural sensory feedback in bidirectional hand prostheses
Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Ivo Strauss, Giacomo Valle, Francesco Iberite, Edoardo D'Anna
Recent studies have shown that direct nerve stimulation can be used to provide sensory feedback to hand amputees. The intensity of the elicited sensations can be modulated using the amplitude or frequency of the injected stimuli. However, a comprehensive c ...
NATURE PUBLISHING GROUP2018Modulating NAD(+) metabolism, from bench to bedside
Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD ...
Wiley2017High sensitivity field asymmetric ion mobility spectrometer
Jürgen Brugger, Giovanni Boero, Philippe Marmillod, Alessandro Valentino Matheoud, Mario Andres Chavarria Varon
A high sensitivity field asymmetric ion mobility spectrometer (FAIMS) was designed, fabricated, and tested. The main components of the system are a 10.6 eV UV photoionization source, an ion filter driven by a high voltage/high frequency n-MOS inverter circ ...
American Institute of Physics2017Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection
Giovanni Dietler, Hilal Lashuel, Sandor Kasas, Anne-Laure Mahul Mellier, Giovanni Longo, Francesco Simone Ruggeri
Cells are extremely complex systems able to modify actively their metabolism and behaviour in response to environmental conditions and stimuli, such as pathogenic agents or drugs. The comprehension of these responses is central to understand the molecular ...
Springer Nature2017