Systematic characterization of flux and network thermodynamic states for identification of metabolic engineering targets
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Study of a metabolic network with respect to the sensitivity of the metabolite concentrations and the metabolic fluxes to genetic, biochemical, and environmental variations requires knowledge of the kinetic properties of the enzymes in the network. Experim ...
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Recent advancements in metabolomics and fluxomics methods and ever-increasing amount of available experimental data necessitate systems-oriented methodologies for efficient and systematic integration of data into consistent large-scale kinetic models capab ...
Thermodynamic analysis of metabolic networks has recently generated increasing interest for its ability to add constraints on metabolic network operation, and to combine metabolic fluxes and metabolite measurements in a mechanistic manner. Concepts for the ...
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