A Handheld beta(+) Probe for Intra-Operative Detection of Radiotracers

Claudio Bruschini, Edoardo Charbon, Christian Mester
Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa, 2011
Article de conférence

Résumé

A handheld probe for direct positron detection based on scintillators coupled to silicon photomultipliers (SiPMs) is presented in this paper. The battery-powered system is optimised for intra-operative use. It is fully sterilisable and wirelessly connected to a PC running a graphical user interface. Successful pilot clinical trials have shown the use in oncological surgery.

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https://infoscience.epfl.ch/record/178671?ln=fr

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A Handheld Intra-Operative beta(+) Sensing System

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We present a new, handheld system for in vivo detection of radiotracers. The detection is based on scintillators coupled to Silicon Photomultipliers (SiPMs) and aimed at direct positron detection. The battery-powered system is wire-lessly connected to a PC. A graphical user interface allows controlling the probe functions and monitoring count rates, battery voltage and temperature. The probe is fully compatible with standard sterilisation procedures and has been successfully used in pre-clinical trials with human cancer patients. The use of the probe requires that the patient be administered a dose of the radiopharmaceutical F-18-fluorodeoxyglucose (FDG), a beta(+) emitting glucose analogue used for detecting tumours in oncology, which can still be detected during the operation. (C) 2011 Published by Elsevier Ltd.

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A Handheld Probe for beta(+)-Emitting Radiotracer Detection in Surgery, Biopsy and Medical Diagnostics based on Silicon Photomultipliers

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We present a new, handheld probe for radiotracer detection in vivo and inside operating theatres, where PET scanners cannot be used for radioguided surgery. The device is based on scintillation detectors optically coupled to Silicon Photomultipliers (SiPMs). It is wirelessly connected to a PC, which, among other functions, optimises operating voltages to compensate for changes of the detector temperature. The probe is primarily aimed at and optimised for direct detection of beta(+) radiation at short distances. Nevertheless, it is also sensitive to gamma, thus enabling the surgeon to localise tumours roughly at larger distances. The use of the probe has been demonstrated in first preclinical pilot trials with oncologic patients at the CHUV university hospital.

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A Handheld beta(+) Probe for Intra-Operative Detection of Radiotracers

les s

A Handheld Intra-Operative beta(+) Sensing System

A Handheld Probe for beta(+)-Emitting Radiotracer Detection in Surgery, Biopsy and Medical Diagnostics based on Silicon Photomultipliers

A Handheld Probe for beta(+)-Emitting Radiotracer Detection in Surgery, Biopsy and Medical Diagnostics based on Silicon Photomultipliers

A Handheld Intra-Operative beta(+) Sensing System