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A brain-machine interface (BMI) is about transforming neural activity into action and sensation into perception (Figure 1). In a BMI system, neural signals recorded from the brain are fed into a decoding algorithm that translates these signals into motor o ...
Since the first compartmentalized neuronal culture described by Robert B. Campenot in 1977, compartmentalized microfluidic devices have been widely used to engineer the cellular environment for cell culture. In previous research by Dr. Anja Kunze, a microf ...
This study aimed at testing the hypothesis that reactive biomechanical responses elicited by unexpected slipping-like perturbations delivered during steady walking are characterized by an intersegmental coordination strategy resembling that adopted during ...
Implantable neuroprostheses are engineered systems designed to restore or substitute function for individuals with neurological deficits or disabilities. These systems involve at least one uni-or bidirectional interface between a living neural tissue and a ...
Various Synaptotagmin (Syt) isoform genes are found in mammals, but it is unknown whether Syts can function redundantly in a given nerve terminal, or whether isoforms can be switched during the development of a nerve terminal. Here, we investigated the pos ...
Human cell reprogramming technologies offer access to live human neurons from patients and provide a new alternative for modeling neurological disorders in vitro. Neural electrical activity is the essence of nervous system function in vivo. Therefore, we e ...
Individuals with severe neurologic injuries often cannot participate in robotic rehabilitation because they do not retain sufficient residual motor control to initiate the robotic assistance. In these situations, brain- and body-computer interfaces have em ...
Regenerative peripheral nerve interfaces are particularly invasive implant devices. They rely on the growth of axons from transected nerve stumps through electrode-bearing structures in order to establish highly efficient communication channels with the ne ...
The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic understanding is still lacking. However, neurodegenerative diseases such as Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) al ...
The idea that intentions make the difference between voluntary and non-voluntary behaviors is simple and intuitive. At the same time, we lack an understanding of how voluntary actions actually come about, and the unquestioned appeal to intentions as discre ...
