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DprE1 as a Drug Target from Mycobacterium Tuberculosis

Publications associées (37)

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An immune-responsive Serpin regulates the melanization cascade in Drosophila

Bruno Lemaitre

In arthropods, the melanization reaction is associated with multiple host defense mechanisms leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activate ...

Elsevier2002

Inter- and intramolecular domain interactions of the catalase-peroxidase KatG from M. tuberculosis

Kai Johnsson, Martin Wilming

The inter- and intramol. interactions between the different domains of the catalase-peroxidase KatG from Mycobacterium tuberculosis were analyzed using the two-hybrid assay. It was shown that the dimerization of the enzyme is due to a strong interaction of ...

2001

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

Varun Sharma, John McKinney

Isocitrate lyase (ICL) plays a pivotal role in the persistence of Mycobacterium tuberculosis in mice by sustaining intracellular infection in inflammatory macrophages. The enzyme allows net carbon gain by diverting acetyl-CoA from beta-oxidation of fatty a ...

2000

Wild-type catalase-peroxidase KatG from Mycobacterium tuberculosis as well as a specific mutant (R463L) frequently found in isoniazid-resistant strains have been overexpressed in Escherichia coli, allowing purifn. of sufficient quantities of enzyme for phy ...

1997

Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.

Stewart Cole

Mutations to the regulatory region of the ahpC gene, resulting in overproduction of alkyl hydroperoxide reductase, were encountered frequently in a large collection of isoniazid (INH)-resistant clinical isolates of Mycobacterium tuberculosis but not in INH ...

1997

Tuberculosis has resurged during the past decade in many industrialized countries, and strains of Mycobacterium tuberculosis that are resistant to one or more of the main antituberculous drugs are emerging. The molecular basis of mycobacterial drug resista ...

1994

The enzymic oxidn. of isoniazid by the catalase-peroxidase of Mycobacterium tuberculosi was studied. The reaction products suggest two reaction pathways involving both electrophilic and radical species. Labeling expts. are consistent with a reaction mechan ...

1994