Publication
Self-assembling SAS-6 multimer is a core centriole building block
Publications associées (55)
Centriole assembly at a glance
Pierre Gönczy, Georgios Hatzopoulos
The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article and accom ...
2019Stabilization of overlapping biofilaments by passive crosslinkers
The formation, maintenance and reorganization of the cytoskeletal filament network is essential for a number of cellular processes. While the crucial role played by active forces generated by motor proteins has been studied extensively, only recently the i ...
2018Integrative approach to analyze the proximal region of the Trichonympha agilis centriole
The centrosome, the major microtubule organizing center in animal cells, is composed of two orthogonally arranged centrioles and surrounding pericentriolar material. Centrioles are evolutionary conserved organelles characterized by a nine-fold symmetry of ...
EPFL2018Cell-free reconstitution reveals centriole cartwheel assembly mechanisms
Henning Paul-Julius Stahlberg, Pierre Gönczy, Paul Guichard, Mircea Ioan Iacovache, Virginie Hamel, Niccolo Banterle, Isabelle Fluckiger, Veronika Nemcíková Villímová
How cellular organelles assemble is a fundamental question in biology. The centriole organelle organizes around a nine-foldsymmetrical cartwheel structure typically 100 nm high comprising a stack of rings that each accommodates nine homodimers of SAS-6 pro ...
Springer Nature2017Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis
Pierre Gönczy, Romain Hamelin, Florence Armand, Coralie Busso, Paul Guichard, Virginie Hamel, Isabelle Fluckiger
Centrioles are evolutionarily conserved macromolecular structures that are fundamental to form cilia, flagella, and centrosomes. Centrioles are 9-fold symmetrical microtubule-based cylindrical barrels comprising three regions that can be clearly distinguis ...
2017Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes
Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live ...
2016Mechanisms of centrosome separation in C. elegans
Centrosomes are the major microtubule organizing centers of animal cells. The two centrosomes present at the onset of mitosis must separate in a timely fashion along the nuclear envelope to ensure proper bipolar spindle assembly and thus genome stability. ...
EPFL2016Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number
Kai Johnsson, Pierre Gönczy, Michele Graciotti, Zhou Fang
Centrioles are microtubule-based organelles found in most eukaryotic cells and that are critical for the formation of cilia and flagella, as well as of centrosomes in animal cells. The number of centrioles must be strictly regulated in proliferating cells ...
Wiley-Blackwell2016Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation
Pierre Gönczy, Alessandro De Simone
The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...
Elsevier2016Computational support for a scaffolding mechanism of centriole assembly
Pierre Gönczy, Paul Guichard, Virginie Hamel
Centrioles are essential for forming cilia, flagella and centrosomes. Successful centriole assembly requires proteins of the SAS-6 family, which can form oligomeric ring structures with ninefold symmetry in vitro. While important progress has been made in ...
2016