Publication
Frequency and dendritic distribution of autapses established by layer 5 pyramidal neurons in the developing rat neocortex: comparison with synaptic innervation of adjacent neurons of the same class
Publications associées (119)
The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex
Henry Markram, Sean Lewis Hill, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Werner Alfons Hilda Van Geit, James Gonzalo King, Marwan Muhammad Ahmed Abdellah, Lida Kanari, Julian Charles Shillcock, Ying Shi, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, John Richard Walker, Michael Emiel Gevaert, Idan Segev, Yun Wang, Giuseppe Chindemi, Juan Bautista Hernando Vieites, Stefan Eilemann, Martin Telefont, Ahmet Bilgili, Guy Antoine Atenekeng Kahou, Nicolas Antille, Raphael Dumusc, Jeffrey Christopher Muller, Jafet Villafranca Diaz, Selim Arsever, Joseph William Graham, Athanassia Chalimourda, Stefano Zaninetta, Yury Brukau, Stanislaw Ryszard Adaszewski
We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...
Frontiers Research Foundation2015An algorithm to predict the connectome of neural microcircuits
Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King
Experimentally mapping synaptic connections, in terms of the numbers and locations of their synapses and estimating connection probabilities, is still not a tractable task, even for small volumes of tissue. In fact, the six layers of the neocortex contain ...
Frontiers Research Foundation2015High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex
Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than roden ...
Public Library Science2014In vivo measurement of excitatory synaptic transmission between identified neurons in layer 2/3 mouse barrel cortex
The neocortex is the most distinctive feature of the mammalian brain and it is considered to be the substrate of high-order cognitive functions. The nature and the arrangement of the diverse neuronal elements constituting its multiple areas have received l ...
EPFL2014Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex
Henry Markram, Yun Wang, Shruti Muralidhar
Layer 1 of the neocortex is sparsely populated with neurons and heavily innervated by fibers from lower layers and proximal and distal brain regions. Understanding the potential functions of this layer requires a comprehensive understanding of its cellular ...
Frontiers Research Foundation2014Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits
Layer 5 thick tufted pyramidal cells (TTCs) in the neocortex are particularly electrically complex, owing to their highly excitable dendrites. The interplay between dendritic nonlinearities and recurrent cortical microcircuit activity in shaping network re ...
Oxford University Press2014The Relationship between PSD-95 Clustering and Spine Stability In Vivo
The appearance and disappearance of dendritic spines, accompanied by synapse formation and elimination may underlie the experience-dependent reorganization of cortical circuits. The exact temporal relationship between spine and synapse formation in vivo re ...
Soc Neuroscience2014Learning improvement after PI3K activation correlates with de novo formation of functional small spines
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide ...
2014Differential behavioral and physiological effects of anodal transcranial direct current stimulation in healthy adults of younger and older age
Changes in γ-aminobutyric acid (GABA) mediated synaptic transmission have been associated with age-related motor and cognitive functional decline. Since anodal transcranial direct current stimulation (atDCS) has been suggested to target cortical GABAergic ...
2014Spike-timing prediction in cortical neurons with active dendrites
Wulfram Gerstner, Richard Naud, Brice Bathellier
A complete single-neuron model must correctly reproduce the firing of spikes and bursts. We present a study of a simplified model of deep pyramidal cells of the cortex with active dendrites. We hypothesized that we can model the soma and its apical dendrit ...
Frontiers Research Foundation2014