Spontaneous recovery of deficits in spatial memory and cholinergic potentiation of NMDA in CA1 neurons during chronic lithium treatment
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Cognitive skills are the emergent property of distributed neural networks. The distributed nature of these networks does not necessarily imply a lack of specialization of the individual brain structures involved. However, it remains questionable whether di ...
The brain is a complex biological system composed of a multitude of microscopic processes, which together give rise to computational abilities observed in everyday behavior. Neuronal modeling, consisting of models of single neurons and neuronal networks at ...
Background The estimation of relative distance is a perceptual task used extensively in everyday life. This important skill suffers from biases that may be more pronounced when estimation is based on haptics. This is especially true for the blind and visua ...
Memory is an essential component of cognition and disorders of memory have significant individual and societal costs. The Atkinson-Shiffrin "modal model" forms the foundation of our understanding of human memory. It consists of three stores: Sensory Memory ...
We consider two schematic models of glasses subjected to oscillatory shear deformation, motivated by the observations, in computer simulations of a model glass, of a nonequilibrium transition from a localized to a diffusive regime as the shear amplitude is ...
Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in structural and functi ...
Cold Spring Harbor Lab Press, Publications Dept2013
Lesions to the anterior thalamic nuclei (ATN) in rats produce robust spatial memory deficits that reflect their influence as part of an extended hippocampal system. Recovery of spatial working memory after ATN lesions was examined using a 30-day administra ...
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate ...
Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar disorders. XBP1 is a major regulator of ...
The hippocampal dentate gyrus (DG) is one of the two sites where neurogenesis continues throughout life in the mammalian brain. Accumulating evidence suggests a unique contribution of adult-generated dentate neurons in hippocampal synaptic plasticity and h ...
