Attomolar protein detection using a magnetic bead surface coverage assay
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The main aim of this project was to develop novel concepts for miniaturization of bioanalytical techniques for investigating biomolecular interactions. We used optical tweezers to selectively address individual biological objects in microfluidic channels. ...
A microchip reactor has been developed on the basis of a layer-by-layer approach for fast and sensitive digestion of proteins. The resulting peptide analysis has been carried out by matrix-assisted laser desorption ionization timeof- flight mass spectromet ...
Micro manipulation tasks with micro tweezers were operated in different configurations. This paper discusses the main issues of pick and place operations with micro tweezers as geometric consideration, grasping force and quality of the contact surfaces. Th ...
We present a technology for the fabrication of three dimensional microfluidic channels in optically transparent substrates consisting of polymers with different properties. The microstructures are fabricated using polymer replication techniques with a view ...
We present a technology for the fabrication of three dimensional microfluidic channels in optically transparent substrates consisting of polymers with different properties. The microstructures are fabricated using polymer replication techniques with a view ...
Microfluidic devices are increasingly used to perform biological experiments on a single-cell basis. However, long-term stability of cell positions is still an issue. A novel biocompatible method for cell entrapment and release on a microchip is presented. ...
We present an original concept of manipulation of magnetic microbeads in a microchannel. It is based on the dynamic motion of a self-assembled structure of ferrimagnetic beads that are retained within a microfluidic flow using a local alternating magnetic ...