Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

Paul Joseph Dyson, Rosario Scopelliti, Alexey Nazarov, Mathurin Baquié, Daniel Gardini
2013
Article

Résumé

Two hybrid compounds comprising an antimetastatic rutheniumarene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.

Source officielle

https://infoscience.epfl.ch/record/185208?ln=fr

À propos de ce résultat

Cette page est générée automatiquement et peut contenir des informations qui ne sont pas correctes, complètes, à jour ou pertinentes par rapport à votre recherche. Il en va de même pour toutes les autres pages de ce site. Veillez à vérifier les informations auprès des sources officielles de l'EPFL.

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Mechanical Properties and Nanomotion of BT-20 and ZR-75 Breast Cancer Cells Studied by Atomic Force Microscopy and Optical Nanomotion Detection Method

Multitarget-Directed Gallium(III) Tris(acyl-pyrazolonate) Complexes Induce Ferroptosis in Cancer Cells via Dysregulation of Cell Redox Homeostasis and Inhibition of the Mevalonate Pathway

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation