Intrinsically photosensitive retinal ganglion cells: classification, function and clinical implications
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Progressive degeneration of photoreceptors is one of the major causes of adult blindness in “industrialized” countries; as an example, Retinitis pigmentosa defines a set of monogenic hereditary retinal diseases, with a prevalence of 1:4000 worldwide, cause ...
The goal of this thesis is to develop a computer-based lighting simulation framework capable of predicting human non-visual responses to light and to validate novel guidelines that can inform designers about how lighting might affect human non-visual respo ...
This paper describes a climate-based simulation framework devised to investigate the potential for the non-visual effects of daylight in buildings. It is part 2 of a study where the first paper focused on the formulation of the photobiological underpinning ...
The retina is one of the best known quantum detectors with rods able to reliably respond to single photons. However, estimates on the number of photons eliciting conscious perception, based on signal detection theory, are systematically above these values ...
This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on nonvisual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic neuropat ...
Purpose: Sight restoration is one of the new frontiers for prosthetic devices that enable the electrical stimulation of neurons. In particular, diseases affecting the retinal pigment epithelium and photoreceptors but preserve the inner retinal layers are p ...
Lighting is one of the most significant factors in the built environment that affect human health and wellbeing. In addition to stimulating visual responses, light induces a range of non-visual responses in humans including synchronizing circadian rhythms ...
We previously developed a Camera-Like Light Sensor (CLLS) to record images using a novel High Dynamic Range (HDR) imaging vision sensor. The device was equipped with customized filters for adapting the camera’s spectral sensitivity to both photopic and cir ...
Sight restoration is one of the new frontiers for prosthetic devices that enable the electrical stimulation of neurons. In particular, diseases that affect the retinal pigment epithelium and photoreceptors but preserve the inner retinal layers are preferen ...
We compared the pupil responses originating from outer versus inner retinal photoreception between patients with isolated hereditary optic neuropathy (HON, n = 8) and healthy controls (n = 8). Three different testing protocols were used. For the first two ...