Phase contrast radiography of Lewy bodies in Parkinson disease
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The interplay between dopamine and alpha-synuclein (AS) plays a central role in Parkinson's disease (PD). PD results primarily from a severe and selective devastation of dopaminergic neurons in substantia nigra pars compacta. The neuropathological hallmark ...
Imaging with visible light today uses numerous contrast mechanisms, including bright- and dark-field contrast, phase-contrast schemes and confocal and fluorescence-based methods. X-ray imaging, on the other hand, has only recently seen the development of a ...
Parkinson's disease (PD) is a neurologic disorder resulting from the loss of dopaminergic neurons in the brain. Two lines of evidence suggest that the protein alpha-synuclein plays a role in the pathogenesis of PD: Fibrillar alpha-synuclein is a major comp ...
Parkinson's disease (PD) is a common progressive neurodegenerative disorder characterized clinically by the combination of motor symptoms like bradykinesia, tremor, rigidity and postural instability. The pathology of PD is related to the degeneration of do ...
Parkinson's disease (PD) is characterized by a progressive loss of midbrain dopamine neurons and the presence of cytoplasmic inclusions called Lewy bodies. Mutations in several genes including alpha-synuclein and parkin have been linked to familial PD. The ...
The patented Nanoconverter is as planar flexure-based structure that attenuates linear movement amplitudes by a large constant reduction factor that can be chosen by design typically between 20 and 1000. It allows using conventional commercial actuators wi ...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of the dopaminergic nigrostriatal pathway and the abnormal appearance of intracellular inclusions named Lewy bodies (LBs). Over the past few years, the d ...
Can individual cells, including live cells, be imaged using hard x rays? Common wisdom until now required sophisticated staining techniques for this task. We show instead that individual cells and cell details can be detected in culture solution and tissue ...
We describe the general characteristics and the first result of a new synchrotron beamline at the Pohang Light Source in Korea. The beamline, operated by a Korean-Taiwanese-Swiss consortium, is dedicated to microimaging experiment in real time with coheren ...
We used phase contrast radiography to study the electro-deposition of Zn in real time and with high lateral resolution. Using unmonochromatic synchrotron X-rays and an optics-less imaging setup, we were able to obtain real-time radiographs of the electro-d ...
