Publication
Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS
Publications associées (65)
Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy
Cristina Ramona Cudalbu, Jocelin Grosse, Katarzyna Pierzchala, Veronika Rackayová
Background & Aims: The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal change ...
2019FM19G11-Loaded Gold Nanoparticles Enhance the Proliferation and Self-Renewal of Ependymal Stem Progenitor Cells Derived from ALS Mice
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. In ALS mice, neurodegeneration is associated with the proliferative restorative attempts of ependymal stem progenitor cells (epSPCs) that normally lie i ...
2019A Cell Atlas for the Mouse Brain
Henry Markram, Daniel Keller, Marc-Oliver Gewaltig
Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. ...
2018Mitochondrial Dynamics: Shaping Metabolic Adaptation
Despite their classic bean-shaped depiction, mitochondria have very different aspects in each cell type. From long filamentous structures to punctuated small round organelles. These shapes can dynamically change in response to nutrients and in situations o ...
ELSEVIER ACADEMIC PRESS INC2018Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model
Cell replacement therapies for neurodegenerative disease have focused on transplantation of the cell types affected by the pathological process. Here we describe an alternative strategy for Parkinson's disease in which dopamine neurons are generated by dir ...
2017Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex
Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and di ...
Cell Press2017Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors
Astrocytes can both sense and shape the evolution of neuronal network activity and are known to possess unique ion regulatory mechanisms. Here we explore the relationship between astrocytic intracellular pH dynamics and the synchronous network activity tha ...
Soc Neuroscience2016Regulation Of Neuron-Astrocyte Metabolic Coupling Across The Sleep-Wake Cycle
Pierre Magistretti, Jean-Marie Petit
Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under th ...
Elsevier2016Astrocyte scar formation aids central nervous system axon regeneration
Mark Andrew Anderson, Michael V. Sofroniew
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte sca ...
Nature Publishing Group2016Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature.Here,we have use ...
2015