Molecular and cell-based therapies for muscle degenerations: a road under construction

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Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...

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Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

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Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...

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Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

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Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

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Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

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Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

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Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

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Evaluation of antigravitational support levels provided by a passive upper-limb occupational exoskeleton in repetitive arm movements

Giulia Ramella

Elsevier Sci Ltd2024

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Michele De Palma

Nature Portfolio2024

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Luc Reymond, Fabien Kuttler, Milena Maria Schuhmacher, Manon Sandra Bardyn, Daria Korotkova, Triana Amen

Nature Research2024