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Metabolic Characterization of a Sirt5 deficient mouse model

Publications associées (33)

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Mitochondrial sirtuins and metabolic homeostasis

Johan Auwerx, Eija Riitta Pirinen, Giuseppe Lo Sasso

The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting but al ...

Elsevier Sci Ltd2012

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

Johan Auwerx, Carlos Canto Alvarez

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this inf ...

2012

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Johan Auwerx, Carlos Canto Alvarez, Hiroyasu Yamamoto

SIRT1 is a NAD+-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here, we tested whether deletion of PARP-2, an alternative NAD+-consuming enzyme, impacts on NAD+ bioavailability and SIRT1 acti ...

Elsevier2011

Cells respond to stress by coordinating proliferative and metabolic pathways. Starvation restricts cell proliferative (glycolytic) and activates energy productive (oxidative) pathways. Conversely, cell growth and proliferation require increased glycolytic ...

2011

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SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to ...

Elsevier2011

The biological function of most proteins relies on reversible post-translational modifications, among which phosphorylation is most prominently studied and well recognized. Recently, a growing amount of evidence indicates that acetylation-deacetylation rea ...

Elsevier2010

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

Johan Auwerx, Carlos Canto Alvarez, Richardus Houtkooper

A century after the identification of a coenzymatic activity for NAD(+), NAD(+) metabolism has come into the spotlight again due to the potential therapeutic relevance of a set of enzymes whose activity is tightly regulated by the balance between the oxidi ...

Endocrine Society2010

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

Johan Auwerx, Kristina Schoonjans, Ellen Helena Jeninga

rganisms adapt their metabolism to meet ever changing environmental conditions. This metabolic adaptation involves at a cellular level the fine tuning of mitochondrial function, which is mainly under the control of the transcriptional co-activator prolifer ...

2010

The role of sirtuins in the control of metabolic homeostasis

Johan Auwerx, Jiujiu Yu

Recently the function of the sirtuin family, named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2), has received a lot of attention, as their beneficial impact on longevity was linked to their effects on meta ...

2009

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases that target multiple protein substrates to execute diverse biological functions. These enzymes are key regulators of clinically important cellular and org ...

Springer Verlag2008