Design and Synthesis of 16-Membered Cyclopeptides Active Against Vancomycin-resistant Enterococci (VRE)
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Bicyclic peptide ligands are promising molecules for the development of new therapeutics. They combine advantages from large protein therapeutics and small molecule drugs. Large combinatorial libraries of bicyclic peptides can be generated and screened by ...
The structural, spectroscopic, and electrochemical properties of [Co{(naph)(2)dien}(N-3)] and [Co{(naph)(2)dpt}(N-3)], where (naph)(2)dien=bis-(2-hydroxy-1-naphthaldimine)-N-diethylenetriaminedianion and (naph)(2)dpt=bis-(2-hydroxy-1-naphthaldimine)-N-dipr ...
Tuberculosis is considered to be one of the world's deadliest disease with 2 million deaths each year. The need for new antitubercular drugs is further exacerbated by the emergence of drug-resistance strains. Despite multiple recent efforts, the majority o ...
The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond, 5 stereogenic ...
Increasing numbers of multiresistant bacterial pathogens cause severe health problems on a global scale. Large quantities of bacteria and their resistance genes are discharged into natural environments via human and animal waste. Not much is known so far a ...
In the latest years the importance of high resolution analysis of the microbial cell surface has been increasingly recognized. Indeed, in order to better understand bacterial physiology and achieve rapid diagnostic and treatment techniques, a thorough inve ...
The aim of this study was to assess the most relevant time scales of antibiotics concentration variations at the sewage treatment plant (STP) inlet and to create a model for the simulation of short-term concentration variations. During one year six antibio ...
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined tempor ...
Objectives To develop a high throughput screening-compatible assay for the selection of species-specific antibiotics that do not harm human cells. Methods Staphylococcus aureus and human reporter cells continuously generating a fluorescence signal were com ...
Bacteria can survive on hospital textiles and surfaces, from which they can be disseminated, representing a source of health care-associated infections (HCAIs). Surfaces containing copper (Cu), which is known for its bactericidal properties, could be an ef ...