Publication
Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency
Publications associées (45)
Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles
Francesco Stellacci, Paulo Henrique Jacob Silva, Quy Ong Khac, Xufeng Xu, Rémi Andréa La Polla, Heyun Wang
We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...
San Diego2023Human PBMCs Form Lipid Droplets in Response to Spike Proteins
Florian Maria Wurm, Guillaume Raussin
Intracellular lipid droplets (LDs) can accumulate in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood mononuclear ...
Basel2023Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism
Francesco Stellacci, Matteo Gasbarri, Valeria Cagno
Heparin has been known to be a broad-spectrum inhibitor of viral infection for almost 70 years, and it has been used as a medication for almost 90 years due to its anticoagulant effect. This nontoxic biocompatible polymer efficiently binds to many types of ...
AMER CHEMICAL SOC2022Diverse cell-specific patterns of alternative polyadenylation in Drosophila
Most genes in higher eukaryotes express isoforms with distinct 3' untranslated regions (3' UTRs), generated by alternative polyadenylation (APA). Since 3' UTRs are predominant locations of post-transcriptional regulation, APA can render such programs condi ...
NATURE PORTFOLIO2022New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction
Hematopoietic Stem and Progenitor Cells (HSPCs) reside in their niche, a structure that regulates the balance of cellular quiescence, self-renewal and commitment towards differentiated cells. This highly plastic niche is formed by several cellular players, ...
EPFL2022High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Gerardo Turcatti, Fabien Kuttler
Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- ...
2022