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In visual backward masking, a briefly presented target is followed by a mask, which impairs target discrimination. Backward masking is strongly impaired in schizophrenic patients and their unaffected relatives. We found that masking deficits correlated well with a mutation (SNP) related to the cholinergic nicotinic receptor alpha 7 subunit and strongly reduced amplitudes in the EEG (Bakanidze et al., 2013; Plomp et al., 2013). This is why visual masking is a potential endophenotype of schizophrenia. Here we tested the brain activity during this task in 24 healthy students with high (N=12) and low scores (N=12) in self-reported cognitive disorganization, one of the three schizotypy dimensions.
Michael Herzog, Simona Adele Garobbio, Maya Roinishvili
Michael Herzog, Simona Adele Garobbio, Maya Roinishvili, Ophélie Gladys Favrod
Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Farnaz Delavari, Karin Bortolin, Emeline Mullier