TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner
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Pseudomonas entomophila is an entomopathogenic bacterium that is lethal to Drosophila melanogaster within 1-2 days of ingestion of high doses. Flies orally infected with P. entomophila rapidly succumb despite the induction of both local and systemic immune ...
This work constitutes the first extended analysis of the spatial structure of Type-I ELM filament footprints on the JET outer limiters and upper dump plates. The data is obtained using a wide angle infrared diagnostic (with time resolution of 125 Hz) and c ...
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about s ...
Purpose: To describe a new type of stent consisting of a 3-dimensional (3D) braided tube made of 2 interconnected layers without any covering to treat a renal artery aneurysm. ...
Upon detection of viral RNA, the helicases RIG-I and/or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce an antiviral type I interferon ...
The present article evaluates the knowledge that can be attributed to the application of « Best Practices » in the field of urban habitat. It especially aims at identifying the conditions of innovation in such a setting, as well as defining the necessary c ...
After more than a century of research, the mechanisms underlying visual masking are still hotly debated. One key characteristic of masking is that variations in the stimulus onset asynchrony (SOA) between the target and the mask can lead to either monotoni ...
Association for Research in Vision and Ophthalmology2007
Early stages of hot-electron thermalization in small gold nanoparticles wrapped in an adsorbates shell have been investigated by femtosecond transient absorption spectroscopy. Type-I hot electrons thermalize in 800 fs (to form type-II hot electron) either ...
The preparation of oligoribonucleotides is of great interest for structural and functional investigations in biomolecular chemistry and biology. Relevant RNAs are relatively long and contain often modifications. Two methods for their preparation are curren ...
Typically, immune responses control the pathogen, while repair and stress pathways limit damage caused by pathogenesis. The relative contribution of damage to the outcome of pathogenesis and the mechanistic links between the immune and repair pathways are ...