Publications associées à Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

FRONTIERS MEDIA SA2022

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Matthias Lütolf, Jeffrey Alan Hubbell, Yoji Tabata, Jun Ishihara, Kazuto Fukunaga

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

AMER SOC HEMATOLOGY2019

Periostin Limits Tumor Response to VEGFA Inhibition

Michele De Palma, Ioanna Keklikoglou, Ece Kadioglu, Axel Bellotti

Resistance to antiangiogenic drugs limits their applicability in cancer therapy. Here, we show that revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are depen ...

Elsevier B.V.2018

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Jeffrey Alan Hubbell, Melody Swartz, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Manuel Andreas Fankhauser

Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...

2017

Design principles for therapeutic angiogenic materials

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis - the proc ...

Nature Publishing Group2016

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Priscilla Suhasna Maithili Briquez

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016

Study of Antimicrobial Peptide Dendrimers on Wound healing in SKin Tissue Engineering

Philippe Abdel Sayed, Ariane Kaeppeli

Infections are one of the most common complications in burn injuries. In severe burns, the wound surface is optimal for microbial proliferation as the exudate is a protein rich environment. Autograft and cultured grafts are the main treatments used nowaday ...

2015

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Significance: Growth factors are very promising molecules for the treatment of skin wounds. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems may derive from the fa ...

Mary Ann Liebert, Inc2015

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Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Periostin Limits Tumor Response to VEGFA Inhibition

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Reprogramming tumor blood vessels for enhancing immunotherapy

Design principles for therapeutic angiogenic materials

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Study of Antimicrobial Peptide Dendrimers on Wound healing in SKin Tissue Engineering

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Graph Chatbot

Chattez avec Graph Search

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Design principles for therapeutic angiogenic materials

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Periostin Limits Tumor Response to VEGFA Inhibition

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling

Study of Antimicrobial Peptide Dendrimers on Wound healing in SKin Tissue Engineering

Reprogramming tumor blood vessels for enhancing immunotherapy

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine