Publication

Acute systemic rapamycin induces neurobehavioral alterations in rats

Publications associées (58)

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

Kei Sakamoto, Maria Deak, Laurent Bultot

AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of metabolic homeostasis. Activation of AMPK provides beneficial outcomes in fighting against metabolic disorders such as insulin resistance and type 2 diabetes. Currently, t ...

Amer Physiological Soc2014

The molecular chaperone Hsp90-dependent proteome represents a complex protein network of critical biological and medical relevance. Known to associate with proteins with a broad variety of functions termed clients, Hsp90 maintains key essential and oncogen ...

Public Library of Science2013

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

Darlene Goldstein, Meredith Dixon

We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1). ...

Soc Neuroscience2013

Psychobiological Vulnerability to Stress

Maria del Carmen Sandi Perez, Jorge Eduardo Castro Cifuentes

Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...

EPFL2012

Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. The tra ...

Elsevier Science Inc2012

Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, inc ...

Public Library of Science2012

The riddle of style changes in the visual arts after interference with the right brain

Olaf Blanke, Isabella Maria Pasqualini

We here analyze the paintings and films of several visual artists, who suffered from a well-defined neuropsychological deficit, visuo-spatial hemineglect, following vascular stroke to the right brain. In our analysis we focus in particular on the oeuvre of ...

Frontiers Research Foundation2012

The kinome of the human malaria parasite Plasmodium falciparum comprises representatives of most eukaryotic protein kinase groups, including kinases which regulate proliferation and differentiation processes. Despite extensive research on most plasmodial e ...

Wiley-Blackwell2011

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases. The functions of the majority of protein kinases of Plasmodi ...

Birkhäuser-Verlag, Springer2010

Exploration of signaling cycles using dynamic optimization

Dominique Bonvin, Vassily Hatzimanikatis, Benoît Chachuat, Andrijana Radivojevic

One of the basic characteristics of every living system is the ability to respond to extracellular signals. This is carried out through a limited number of protein-based signaling networks, whose function is not based only on simple transmission of the rec ...

2010

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