Publication
Acute systemic rapamycin induces neurobehavioral alterations in rats
Publications associées (58)
Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function
Johan Auwerx, Kristina Schoonjans
Epidermal Langerhans cells (LC) play a pivotal role in initiating and maintaining primary immune responses in the skin. In the present study, we asked whether peroxisome proliferator-activated receptor-alpha (PPARalpha) activation modulates LC function. Ou ...
2007The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth
The receptor-like protein kinase PknB from Mycobacterium tuberculosis is encoded by the distal gene in a highly conserved operon, present in all actinobacteria, that may control cell shape and cell division. Genes coding for a PknB-like protein kinase are ...
2006Use of Virtual Reality as Therapeutic Tool for Behavioral Exposure in the Ambit of Social Anxiety Disorder Treatment.
Daniel Thalmann, Bruno Herbelin, Helena Stephanie Grillon Le Gallennec
We hereby present a study whose aim is to evaluate the efficiency and flexibility of virtual reality as a therapeutic tool in the confines of a social phobia behavioural therapeutic program. Our research protocol, accepted by the ethical commission of the ...
2006Virtual Reality as Therapeutic Tool in the Confines of Social Anxiety Disorder Treatment
Daniel Thalmann, Bruno Herbelin, Helena Stephanie Grillon Le Gallennec
In this paper, we present a study, conducted over 8 social phobic subjects, whose aim is to evaluate the efficiency and flexibility of virtual reality as a therapeutic tool in the confines of a social phobia behavioural therapeutic program. Our research pr ...
2006Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes
The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered ...
2005Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases
The identification of phosphorylation sites in proteins provides a powerful tool to study signal transduction pathways and to establish interaction networks involving signaling elements. Using different strategies to identify phosphorylated residues, we re ...
2005gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site
gamma-Secretase is an unusual protease with an intramembrane catalytic site that cleaves many type I membrane proteins, including the amyloid beta-protein (Abeta) precursor (APP) and the Notch receptor. Genetic and biochemical studies have identified four ...
American Society for Biochemistry and Molecular Biology2005Protein kinases as targets for anti-parasitic chemotherapy
Parasitic protozoa infecting humans have a staggering impact on public health, especially in the developing world. Furthermore, several protozoan species are major pathogens of domestic animals and have a considerable impact on food production. In many ins ...
2004AtSGP1, AtSGP2 and MAP4K alpha are nucleolar plant proteins that can complement fission yeast mutants lacking a functional SIN pathway
Viesturs Simanis, Andrea Krapp
In the fission yeast Schizosaccharomyces pombe, the onset of septum formation is signalled via the septation initiation network (SIN) involving several protein kinases and a GTPase. Arabidopsis thaliana and Brassica napus proteins homologous to fission yea ...
2004Structural and functional evidence for the interaction of insulin-like growth factors (IGFs) and IGF binding proteins with vitronectin
Previous studies demonstrated that IGF-II binds directly to vitronectin (VN), whereas IGF-I binds poorly. However, binding of VN to integrins has been demonstrated to be essential for a range of IGF-I-stimulated biological effects, including IGF binding pr ...
2003