Publication
Strategy to Optimize the Biological Activity of Arene Ruthenium Metalla-Assemblies
Publications associées (58)
Understanding the interactions of diruthenium anticancer agents with amino acids
Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Muhammad Hanif
The dinuclear anticancer agents 1,n-bis{chlorido3-(oxo-kappa O)-2-methyl-4-(1H)-pyridinonato-kappa O4-ruthenium(II)}alkane (PyRu2n) exhibit high antiproliferative activity in human cancer cell. Reactivity studies with DNA and protein rev ...
SPRINGER2018α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes
Paul Joseph Dyson, Lucinda Kate Batchelor
α-Diimines are among the most robust and versatile ligands available in synthetic coordination chemistry, possessing finely tunable steric and electronic properties. A series of novel cationic ruthenium(II) p-cymene complexes bearing simple α-diimine ligan ...
2018The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects
Paul Joseph Dyson, Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Catherine Maclachlan, Gianni Sava
Nanoscale secondary ion mass spectrometry (NanoSIMS) combined with transmission electron microscopy (TEM) can be a powerful approach to visualize the exact distribution of drugs at the sub-cellular level. In this work, we exploit this approach to identify ...
2017Organometallic Glutathione S-Transferase Inhibitors
Paul Joseph Dyson, Rosario Scopelliti, Mylène Soudani, Emilia Paunescu
A new family of organometallic p-cymene ruthenium(II) and osmium(II) complexes conjugated to ethacrynic acid, a glutathione transferase (GST) inhibitor, is reported. The ethacrynic acid moiety (either one or two) is tethered to the arene ruthenium(II) and ...
2017Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells
Deregulation of the TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases (RTKs) has recently been demonstrated to predominately promote survival and chemoresistance of cancer cells. Intramembrane proteolysis mediated by presenilin/gamma-secretas ...
Federation Amer Soc Exp Biol2017Perfluorinated HDAC inhibitors as selective anticancer agents
Paul Joseph Dyson, Tina Riedel
A series of potent histone deacetylase inhibitors is presented that incorporate alkyl or perfluorinated alkyl chains. Several new compounds show greater in vitro antiproliferative activity than the clinically approved inhibitor, SAHA. Furthermore, the new ...
Royal Society of Chemistry2017Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates
Harm-Anton Klok, Claudia Battistella
Inhibition of P-glycoprotein (P-gp) transporter is an attractive approach for the reversion of cancer-associated multidrug resistance (MDR). Poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA)-based carriers that are able to release the anticancer drug doxoru ...
2017Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes
Paul Joseph Dyson, Rosario Scopelliti, Mylène Soudani, Emilia Paunescu, Lucinda Kate Batchelor
Dinudear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinudear ruthenium(II) p-cyrnene and gold(I) complexes, in which ...
2017Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers
Paul Joseph Dyson, Tina Riedel
A series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-L)(2)(mu(4)-OO boolean AND OO)(2)]CF3SO3 (L-1 = N,N'-bis(4-pyridylmethyl)-pyromellitic diimide, L-2 = N,N'-bis(4-pyridylmethyl)-naphthalene diimide) wer ...
Elsevier2016Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance
Paul Joseph Dyson, Mylène Soudani, Tina Riedel
Tetranuclear arene ruthenium complexes of the general formula {Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4) ...
Elsevier Science Sa2016