Neurorehabilitation and neuroprosthetic technologies to regain motor function following spinal cord injury
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In humans, a severe spinal cord contusion interrupts the vast majority of supraspinal projections to the spinal cord below the lesion. Permanent paralysis results from the chronic failure of these spared projections to engage lumbar circuits producing leg ...
Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively b ...
After spinal cord injury (SCI), the communication between the brain and spinal neural circuits below the lesion is disrupted, leading to paralysis. Epidural electrical stimulation (EES) of the lumbosacral spinal cord has been shown to restore locomotion an ...
Our brain constantly receives and integrates a flow of sensory and motor information that shapes the way our body is represented. Several experimental approaches have been proposed to alter the body representation, by manipulating exteroceptive or interoce ...
Spinal cord injury (SCI) remains a global problem, and despite decades of research there currently is no cure for this disease. Recently, significant advances in the use of neuroprosthetic rehabilitation to improve locomotor outcomes after SCI have been ma ...
Neurological disorders such as spinal cord lesion and stroke disturb sensorimotor pathways and result in severe motor deficits that can dreadfully impact the quality of life of affected individuals. Strategies aiming at restoring hand function after upper- ...
Rostro-caudal coordination of spinal motor output is essential for locomotion. Most spinal interneurons project axons longitudinally to govern locomotor output, yet their connectivity along this axis remains unclear. In this study, we use larval zebrafish ...
Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...
Background. An ischemic stroke is followed by the remapping of motor representation and extensive changes in cortical excitability involving both hemispheres. Although stimulation of the ipsilesional motor cortex, especially when paired with motor training ...
Spinal cord injury (SCI) is a life-changing event. People who suffer from it lose their abilityto move normally and are subject to life-threatening symptoms. When the insult is not toosevere, partial recovery is possible. Otherwise, for severely affected p ...
