Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition
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The lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemi ...
We present the first feasibility test of spectromicroscopy on the microlocalization of gadolinium in brain cancer tissue. A gadolinium compound was injected to the patients before the brain tumor was extracted with surgery, and we looked for Gd in the tumo ...
Photodynamic therapy (PDT) for cancer in the esophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, the clin. use of a less penetrating wavelength (514 nm) was investigated for the curative treatment ...
Cutaneous and ocular melanomas are due to malignant transformation of neural crest-derived melanocytes. The rising incidence of this tumor in humans has stimulated experiments to devise suitable mouse models. In the past years, transgenic mouse lines have ...
Boron neutron capture therapy (BNCT) is an experimental, binary treatment far brain cancer which requires as the first step that tumor tissue is targeted with a boron-10 containing compound. Subsequent exposure to a thermal neutron flux results in destruct ...
Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the r ...
Purpose: The present study was initiated to det. the conditions under which a single photodynamic treatment would induce maximal damage to a tumor with no or at least minimal reversible damage to a normal striated muscle. Methods and Materials: The techniq ...
The development of colorectal cancer, one of the most frequent cancers, is influenced by prostaglandins and fatty acids. Decreased prostaglandin production, seen in mice with mutations in the cyclooxygenase 2 gene or in animals and humans treated with cycl ...
In a model of nude mice bearing a human colon carcinoma xenograft, the biodistribution and tumor localization of metatetrahydroxyphenylchlorin (m-THPC) coupled to polyethylene glycol (PEG) were compared with those of the free form of this photosensitizer u ...
Doxorubicin has the widest spectrum of antitumor activity of all antineoplastic agents and is the most utilized anticancer drug worldwide. Unfortunately there are several tumor types that do not respond to doxorubicin and, furthermore, its effectiveness is ...
