Publication
Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury
Publications associées (38)
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Kei Sakamoto, Katyayanee Neopane
SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) inhibitor relative to the widely used, but promiscuous inhibitor Compou ...
2021Characterization of the Renin-Angiotensin System in Aged Cavernosal Tissue and its Role in Penile Fibrosis
Nikolaos Stergiopoulos, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Maiia Bragina, Babak Ebadi Shirmard
Background: The renin-angiotensin system (RAS) plays an important role in erectile function. The RAS contains 2 major axes: one deleterious, composed of ACE-Ang II-AT1 receptor, and another protective, composed of ACE2-Ang-(1-7)-Mas receptor. While aging i ...
ELSEVIER SCI LTD2020Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan
Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez
Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination to the biometal Zn(II), resultin ...
FUTURE SCI LTD2020The gut microbiota influences skeletal muscle mass and function in mice
Johan Auwerx, Hongbo Zhang, Walter Wahli
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...
AMER ASSOC ADVANCEMENT SCIENCE2019Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle
The progressive decline of muscle mass and function called sarcopenia is a multi-factorial process associated to frailty, disability, and low quality of life in the elderly. The co-factor nicotinamide adenine dinucleotide (NAD+) becomes a limiting factor i ...
EPFL2019Muscle Activation Variability Is Inversely Correlated with Walking Speed
Auke Ijspeert, Florin Dzeladini, Amy Roning Wu, Cole Stewart Simpson, Amandine Grappe
Individuals withmotor impairments typically walk at much slower speeds than their unimpaired counterparts, yet their gait data is still evaluated against the relatively faster gait of healthy subjects. Therefore a good understanding of unimpaired gait at e ...
Springer International Publishing Ag2017Metabolic control of muscle and muscle stem cell function
Skeletal muscle composed of myofibers and a small amount of muscle stem cells (MuSCs). It plays important roles in energy metabolism. Some of the key metabolites, such as NAD+ and acetyl-CoA were recently found to regulate muscle and MuSCs function. Most o ...
EPFL2016Mechanical Characterization and Shape Optimization of Fascicle-Like 3D Skeletal Muscle Tissues Contracted with Electrical and Optical Stimuli
In this study, we present a quantitative approach to construct effective 3D muscle tissues through shape optimization and load impedance matching with electrical and optical stimulation. We have constructed long, thin, fascicle-like skeletal muscle tissue ...
2014An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia
Nikolaos Stergiopoulos, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga, Younouss Faye
IntroductionHypercholesterolemia is a prevalent risk factor for the development of erectile dysfunction (ED), mostly due to an increase in oxidative stress and impaired nitric oxide (NO) bioavailability within the penis. Arginase is an enzyme that shares t ...
Wiley-Blackwell2014An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia
Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Danielle Gomes Passos Silva
Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile ...
Wiley-Blackwell2013