Publication
Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum
Publications associées (36)
Developing a Reconciled Genome-Scale Model of the Malaria Parasite Plasmodium falciparum and its Thermodynamics-based Flux Balance Analysis
Vassily Hatzimanikatis, Meriç Ataman, Stepan Tymoshenko, Dominique Soldati-Favre
Understanding the metabolism of the malaria parasites is of high priority to identify novel enzymatic drug targets and face the rise in drug resistant parasites. Based on the knowledge of metabolic functions and molecular interactions, we can reconstruct g ...
2015Regulation of Plasmodium falciparum Development by Calcium-dependent Protein Kinase 7 (PfCDPK7)
Second messengers such as phosphoinositides and calcium are known to control diverse processes involved in the development of malaria parasites. However, the underlying molecular mechanisms and pathways need to be unraveled, which may be achieved by unders ...
Amer Soc Biochemistry Molecular Biology Inc2014Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission
Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. Four CLKs, termed PfCLK-1-4, can be identified in the human malaria parasite Plasmodium ...
Public Library Science2014Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast
Background: The apicoplast is a plastid organelle derived from a secondary endosymbiosis, containing biosynthetic pathways essential for the survival of apicomplexan parasites. The Toxoplasma apicoplast clearly possesses four membranes but in related Plasm ...
Springer Nature2013Functional genomics of Plasmodium falciparum using metabolic modelling and analysis
Vassily Hatzimanikatis, Stepan Tymoshenko, Rebecca Oppenheim, Dominique Soldati-Favre
Plasmodium falciparum is an obligate intracellular parasite and the leading cause of severe malaria responsible for tremendous morbidity and mortality particularly in sub-Saharan Africa. Successful completion of the P. falciparum genome sequencing project ...
Oxford Univ Press2013Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes
Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results. Here, we report expression of PfATP6 (a SERCA pump) in yeast and demonstrate its ...
Oxford University Press2013The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation
Background: Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector. Regulation of the onset ...
Biomed Central Ltd2012Structural basis for chirality and directional motility of Plasmodium sporozoites
Plasmodium sporozoites can move at high speed for several tens of minutes, which is essential for the initial stage of a malaria infection. The crescent-shaped sporozoites move on 2D substrates preferably in the same direction on circular paths giving rais ...
Wiley-Blackwell2012Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
Romain Hamelin, Marc Moniatte, Amit Sharma, Guillem Dayer
Background: Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes. The cellular functions of Plasmodium falciparum CK2 (PfCK2) are unknown. Th ...
2012Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes
P>Merozoites of malaria parasites invade red blood cells (RBCs), where they multiply by schizogony, undergoing development through ring, trophozoite and schizont stages that are responsible for malaria pathogenesis. Here, we report that a protein kinase-me ...
Wiley-Blackwell2011